EFFECT OF EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACIDS ON BLOOD-PRESSURE IN HYPERTENSION - A POPULATION-BASED INTERVENTION TRIAL FROM THE TROMSO STUDY
EFFECT OF EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACIDS ON BLOOD-PRESSURE IN HYPERTENSION - A POPULATION-BASED INTERVENTION TRIAL FROM THE TROMSO STUDY
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DOI：
10.1056/nejm199003223221202
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发表时间：
1990-03-22
影响因子：
158.5
通讯作者：
THELLE, D
中科院分区：
文献类型：
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作者：
BONAA, KH;BJERVE, KS;THELLE, D
关于鱼油中的多不饱和脂肪酸，特别是二十碳五烯酸和二十二碳六烯酸是否能降低血压的研究在设计和结果上各不相同。我们进行了一项基于人群的随机10周饮食补充试验，在156名先前未经治疗的稳定的轻度原发性高血压患者中，将每天6 g 85%的二十碳五烯酸和二十二碳六烯酸的效果与每天6 g玉米油的效果进行了比较。鱼油组平均收缩压下降4.6 mm Hg（P = 0.002），舒张压下降3.0 mm Hg（P = 0.0002）;鱼油组无显著变化;玉米油组无显著变化。在控制了人体测量、生活方式和饮食变量后，两组之间的收缩压（6.4 mm Hg; P - 0.0025）和舒张压（2.8 mm Hg; P = 0.029）仍有显著差异。随着血浆磷脂n-3脂肪酸浓度的增加，血压下降幅度更大（P = 0.027）。膳食补充鱼油并没有改变那些每周吃三次或更多次鱼作为日常饮食的一部分的受试者的平均血压，或者那些血浆磷脂n-3脂肪酸基线浓度高于175.1 mg/L的受试者。我们的结论是，二十碳五烯酸和二十二碳六烯酸降低原发性高血压的血压，这取决于血浆磷脂n-3脂肪酸的增加。
Studies of whether polyunsaturated fatty acids in fish oil-in particular, eicosapentaenoic and docosahexaenoic acids-lower blood pressure have varied in design and results. We conducted a population-based, randomized 10-week dietary-supplementation trial in which the effects of 6 g per day of 85 percent eicosapentaenoic and docosahexaenoic acids were compared with those of 6 g per day of corn oil in 156 men and women with previously untreated stable, mild essential hypertension. The mean systolic blood pressure fell by 4.6 mm Hg (P = 0.002), and diastolic pressure by 3.0 mm Hg (P = 0.0002) in the group receiving fish oil; there was no significant change in the group of receiving fish oil; there was no significant change in the group receiving corn oil. The differences between the groups remained significant for both systolic (6.4 mm Hg; P - 0.0025) and diastolic (2.8 mm Hg; P = 0.029) pressure after control for anthropometric, lifestyle, and dietary variables. The decreases in blood pressure were larger as concentrations of plasma phospholipid n-3 fatty acids increased (P = 0.027). Dietary supplementation with fish oil did not change mean blood pressure in the subjects who ate fish three or more times a week as part of their usual diet, or in those who had a base-line concentration of plasma phospholipid n-3 fatty acids above 175.1 mg per liter. We conclude that eicosapentaenoic and docosahexaenoic acids reduced blood pressure in essential hypertension, depending on increases in plasma phospholipid n-3 fatty acids.