Homeostasis of effector systems which can also be recruited for immunologic reactions.
Homeostasis of effector systems which can also be recruited for immunologic reactions.
复制标题
效应系统的稳态，也可用于免疫反应。
作者：
K. Austen
在非免疫宿主和免疫宿主中，为宿主防御而募集的效应子途径是特异性的，并产生一系列有益功能，但如果反应被误导或过度，它们也可能对宿主有害。这些效应器系统功能失调，从而导致超敏反应的病理状态，不应被视为过度的生理反应，而应视为对系统外部损伤的无意识反应，其性质违反了维持宿主完整性的通常机制。我越来越意识到这两个系统的生理而非病理潜力，即肥大细胞-嗜酸性粒细胞轴，它位于敌对元素可能侵入宿主的门户，以及替代补体途径，它通过生物化学而非免疫化学手段区分自我和非自我，促使我强调它们的稳态功能。
The effector pathways recruited for host defense in both the nonimmune and the immune host are specific and generate an array of beneficial functions, but they can also be detrimental to the host if the response is misdirected or excessive. A maladjustment in function of these effector systems so as to contribute to pathologic states of hypersensitivity is not to be viewed as an excessive physiologic response but rather as an involuntary response to an insult extrinsic to the system and of such a nature as to violate the usual mechanisms for maintaining integrity of the host. My growing awareness of the physiologic rather than the pathologic potential of two such systems, namely the mast cell-eosinophil axis, which is situated at portals of possible host penetration by hostile elements, and the alternative complement pathway which distinguishes self from nonself by biochemical rather than immunochemical means, prompts me to emphasize their homeostatic functions.