Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial
Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial
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DOI：
10.1089/104454603322163844
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发表时间：
2003-06-01
影响因子：
1.9
通讯作者：
Swanson, JM
中科院分区：
文献类型：
--
作者：
Galanter, CA;Carlson, GA;Swanson, JM
目的：最近的报告引起了人们的关注，注意力缺陷多动障碍（ADHD）和一些躁狂症状的儿童可能会因兴奋剂治疗而恶化。本研究探讨哌醋甲酯在这样的children.Methods：数据从儿童参与1个月哌醋甲酯滴定试验的多模式治疗研究ADHD儿童进行了重新分析，分为样本的儿童和没有一些躁狂症状。两个“躁狂代理”的构建使用项目的诊断访谈时间表为儿童（DISC）或儿童行为检查表（CBCL）。治疗反应和副作用之间的参与者和没有proxies.Results比较：32（11%）和29（10%）参与者符合标准的CBCL躁狂症代理和DISC躁狂症代理，分别。存在或不存在任何代理没有预测更大或更小的反应或副作用。结论：研究结果表明，ADHD和躁狂症状的儿童在治疗的第一个月对哌甲酯反应强烈，这些儿童不太可能对哌甲酯产生不良反应。需要进一步的研究来探索这些儿童在长期治疗期间将如何反应。临床医生不应该先验地避免ADHD和一些躁狂症状的儿童使用兴奋剂。
Objective: Recent reports raise concern that children with attention deficit hyperactivity disorder (ADHD) and some manic symptoms may worsen with stimulant treatment. This study examines the response to methylphenidate in such children.Methods: Data from children participating in the 1-month methylphenidate titration trial of the Multimodal Treatment Study of Children with ADHD were reanalyzed by dividing the sample into children with and without some manic symptoms. Two "mania proxies" were constructed using items from the Diagnostic Interview Schedule for Children (DISC) or the Child Behavior Checklist (CBCL). Treatment response and side effects are compared between participants with and without proxies.Results: Thirty-two (11%) and 29 (10%) participants fulfilled criteria for the CBCL mania proxy and DISC mania proxy, respectively. Presence or absence of either proxy did not predict a greater or lesser response or side effects.Conclusion: Findings suggest that children with ADHD and manic symptoms respond robustly to methylphenidate during the first month of treatment and that these children are not more likely to have an adverse response to methylphenidate. Further research is needed to explore how such children will respond during long-term treatment. Clinicians should not a priori avoid stimulants in children with ADHD and some manic symptoms.