RESPONSES OF GASTROINTESTINAL SMOOTH-MUSCLE PREPARATIONS TO A MUSCARINIC PRINCIPLE PRESENT IN SIDA-VERONICAEFOLIA
RESPONSES OF GASTROINTESTINAL SMOOTH-MUSCLE PREPARATIONS TO A MUSCARINIC PRINCIPLE PRESENT IN SIDA-VERONICAEFOLIA
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DOI：
10.1016/0378-8741(88)90011-6
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发表时间：
1988-07-01
影响因子：
5.4
通讯作者：
LUTTERODT, GD
中科院分区：
文献类型：
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作者：
LUTTERODT, GD
研究了黄花稔叶醇提物水溶性部分对离体豚鼠回肠和离体兔十二指肠的作用。使用阿托品、六烃季铵和美吡拉敏进行的激动剂/拮抗剂研究表明，活性成分可能是毒蕈碱样的。对提取物的初步生物化学调查显示生物碱、皂苷和真单宁的存在为阴性结果，但确认了假单宁、寡糖、类黄酮、胆碱、果糖、肽、组氨酸、甘氨酸、酪氨酸、草酸和酚酸的存在。
The effects of the water-soluble fraction from an alcoholic extract of Sida veronicaefolia leaves were studied on isolated guinea-pig ileum and isolated rabbit duodenum. Agonist/antagonist studies, using atropine, hexamethonium and mepyramine, suggest that the active principle may be muscarine-like. Preliminary biochemical investigations on the extract showed negative results for the presence of alkaloids, saponins and true tannins, but confirmed the presence of pseudotannins, oligosaccharides, flavonoids, choline, fructose, peptides, histidine, glycine, tryosine, oxalic acid and phenolic acid.