Aggressive Hydration With Lactated Ringer Solution in Prevention of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis A Meta-analysis of Randomized Controlled Trials
Aggressive Hydration With Lactated Ringer Solution in Prevention of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis A Meta-analysis of Randomized Controlled Trials
复制标题
用乳酸林格液积极水合预防内镜逆行胰胆管造影后胰腺炎：随机对照试验的荟萃分析。
DOI：
10.1097/mcg.0000000000000781
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发表时间：
2017-03-01
影响因子：
2.9
通讯作者：
Deng, Wu-Guo
中科院分区：
文献类型：
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作者：
Zhang, Zhi-Feng;Duan, Zhi-Jun;Deng, Wu-Guo
背景：胰腺炎是内镜逆行胰胆管造影（ERCP）最常见的并发症。先前的研究评估了乳酸林格氏液积极水合作用对降低ERCP术后胰腺炎（PEP）发生率的作用，结果不一致。目的：我们进行了一项荟萃分析，以确定乳酸林格氏液积极水合作用是否降低PEP。方法：随机对照试验（RCT）在PubMed，Embase，科克伦对照试验中心注册库（CENTRAL）和CINAHL数据库。还搜索了ClinicalTrial.gov和国际标准随机对照试验编号登记处以寻找未发表的研究。按照科克伦干预系统评价手册进行Meta分析。结果：共纳入7项随机对照试验，共1047例受试者。荟萃分析显示，与标准水化相比，积极水化降低了PEP的发生率[比值比（OR），0.47; 95%置信区间（CI），0.30-0.72; P=0.0006]。与标准水化相比，积极水化也降低了ERCP术后高淀粉酶血症的发生率（OR，0.38; 95%CI，0.25-0.59; P
Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The results of previous studies evaluating aggressive hydration with lactated Ringer solution for reducing the incidence of post-ERCP pancreatitis (PEP) are inconsistent.Aim: We performed a meta-analysis to determine whether aggressive hydration with lactated Ringer solution reduced PEP.Methods: Randomized controlled trials (RCTs) comparing aggressive hydration with standard hydration with the same lactated Ringer solution for prophylaxis of PEP were searched in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases. ClinicalTrial.gov and International Standard Randomised Controlled Trial Number registry were also searched for unpublished studies. A meta-analysis was conducted in accordance with the Cochrane Handbook for Systemic Reviews of Intervention.Results: A total of 7 RCTs with 1047 participants were included into this meta-analysis. Meta-analysis showed that aggressive hydration reduced the incidence of PEP as compared with standard hydration [odds ratio (OR), 0.47; 95% confidence interval (CI), 0.30-0.72; P=0.0006]. Aggressive hydration also reduced the incidence of post-ERCP hyperamylasemia as compared with standard hydration (OR, 0.38; 95% CI, 0.25-0.59; P