Coupling between prefrontal brain activity and respiratory sinus arrhythmia in infants and adults.
Coupling between prefrontal brain activity and respiratory sinus arrhythmia in infants and adults.
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DOI：
10.1016/j.dcn.2021.101047
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发表时间：
2022-03
影响因子：
4.7
通讯作者：
Abney DH
中科院分区：
文献类型：
--
作者：
Nguyen T;Hoehl S;Bertenthal BI;Abney DH
自我调节是儿童健康发展的一个重要方面。即使婴儿在最初几年依赖于他们的照顾者共同调节，他们开始通过社会互动以及他们自己的认知发展获得早期的调节能力。这些早期的调节能力随着前额叶皮层和迷走神经系统的成熟而继续增强。重要的是，理论解释表明，前额叶皮层和迷走神经系统是通过边缘系统的正向和反向反馈回路联系在一起的。这一环节的耦合减少被认为与精神病理有关。本研究的主要目的是研究前额叶脑活动和呼吸窦性心律失常在婴儿期是否明显。采用功能近红外光谱和心电图同时评估，我们将使用交叉复发量化分析来评估69个4 - 6个月婴儿及其母亲在休息时前额叶脑活动与呼吸性窦性心律失常的耦合。了解自我调节的神经生物学相关的发育出现将使我们能够帮助确定神经发育的危险因素。在成人中，自我调节涉及前额皮质（PFC）和迷走神经活动之间的耦合。我们研究脑和呼吸窦性心律失常（RSA）活动的耦合是否在婴儿期明显。了解PFC和迷走神经系统之间的发展联系将有助于阐明参与自我调节的途径。
Self-regulation is an essential aspect of healthy child development. Even though infants are dependent on their caregivers for co-regulation during the first years, they begin to gain early regulatory abilities through social interactions as well as their own cognitive development. These early regulatory abilities continue to increase with the maturation of both the prefrontal cortex and the vagal system. Importantly, theoretical accounts have suggested that the prefrontal cortex and the vagal system are linked through forward and backward feedback loops via the limbic system. Decreased coupling within this link is suggested to be associated with psychopathology. The primary goal of this study is to examine whether intrapersonal coupling of prefrontal brain activity and respiratory sinus arrythmia is evident in infancy. Using the simultaneous assessment of functional near-infrared spectroscopy and electrocardiography, we will use Cross-Recurrence Quantification Analysis to assess the coupling of prefrontal brain activity and respiratory sinus arrhythmia in 69 4–6-month-old infants and their mothers during rest. Understanding the developmental emergence of the neurobiological correlates of self- regulation will allow us to help identify neurodevelopmental risk factors. In adults, self-regulation involves coupling between the prefrontal cortex (PFC) and vagal activity. We investigate whether the coupling of brain and respiratory sinus arrhythmia (RSA) activity is evident during infancy. Understanding the developing connection between the PFC and vagal system will help to elucidate the pathways involved in self-regulation.
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