Effective, single-dose treatment of porcine cysticercosis with oxfendazole
Effective, single-dose treatment of porcine cysticercosis with oxfendazole
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DOI：
10.4269/ajtmh.1996.54.391
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发表时间：
1996-04-01
影响因子：
3.3
通讯作者：
LopezUrbina, MT
中科院分区：
文献类型：
--
作者：
Gonzales, AE;Garcia, HH;LopezUrbina, MT
猪是猪带绦虫传播周期中至关重要的一环，猪带绦虫是人-猪囊虫病的罪魁祸首。受感染的猪也是发展中国家农民经济损失的重要来源。过去寻找一种适当的治疗方案来治疗这种猪寄生虫病的努力都失败了，原因是疗效低、成本高、副作用或需要多次注射。在这项随机、无治疗对照的研究中，评价了奥芬达唑和吡喹酮对16头自然感染猪囊虫病的疗效和安全性。每组4头猪，分别用奥芬达唑、吡喹酮、奥芬达唑加吡喹酮治疗或不治疗。治疗12周后处死动物，计数包囊数，用包囊外翻法评价寄生虫存活率。在所有的猪身上都没有发现可检测到的副作用。单独的吡喹酮治疗似乎减少了包囊的数量，但并没有降低剩余寄生虫的生存能力。单用奥芬达唑或奥芬达唑加吡喹酮治疗杀死了所有寄生虫，只在肉中留下了微小的钙化。奥芬达唑首次提供了一种实用、有效、廉价和单剂治疗猪囊虫病的方法。
The pig is a vital link in the transmission cycle of Taenia solium, the cestode responsible for human-porcine cysticercosis. Infected pigs also represent an important source of economic loss to farmers in developing countries. Past efforts to find an adequate therapeutic regimen to treat this parasitic disease in swine have failed because of low efficacy, high cost, side effects, or the need for multiple doses. In this randomized, no treatment-controlled study, the efficacy and safety of oxfendazole and praziquantel for the treatment of porcine cysticercosis were evaluated in 16 naturally infected pigs. Four groups of four pigs were treated with oxfendazole, praziquantel, oxfendazole plus praziquantel, or untreated. The pigs were humanely killed 12 weeks post-treatment, the number of cysts was counted, and parasite viability was assessed by cyst evagination. No detectable side effects were seen in any of the pigs. Praziquantel treatment alone appeared to reduce the number of cysts, but did not decrease the viability of the remaining parasites. Treatment with oxfendazole alone or oxfendazole plus praziquantel killed all of the parasites, and left only microcalcifications in the meat. Oxfendazole provides, for the first time, a practical, effective, inexpensive, and single-dose therapy for porcine cysticercosis.