The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons.
The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons.
复制标题
reelin信号通路促进海马神经元中的树突状脊柱发育。
DOI：
10.1523/jneurosci.1917-08.2008
复制
发表时间：
2008-10-08
影响因子：
5.3
通讯作者：
D'Arcangelo, Gabriella
中科院分区：
文献类型：
--
作者：
Niu, Sanyong;Yabut, Odessa;D'Arcangelo, Gabriella
不同细胞层和精确突触回路的发育对于哺乳动物大脑中功能良好的皮质结构的形成至关重要。细胞外蛋白Reelin通过激活包括ApoER 2和VLDLR受体和衔接蛋白Dab 1的核心信号通路，控制径向迁移的主神经元的定位，促进未成熟前脑神经元中树突状突起的延伸，并影响突触传递。在这里，我们报告的第一次，Reelin信号通路促进突触后结构的发展，如树突棘在海马锥体神经元。我们的数据强调了Reelin作为促进目标神经元群体成熟和出生后海马兴奋性回路发展的因素的重要性。这些发现可能对理解与Reelin缺乏相关的认知障碍的起源有影响。
The development of distinct cellular layers and precise synaptic circuits is essential for the formation of well functioning cortical structures in the mammalian brain. The extracellular protein Reelin through the activation of a core signaling pathway including the ApoER2 and VLDLR receptors and the adapter protein Dab1, controls the positioning of radially migrating principal neurons, promotes the extension of dendritic processes in immature forebrain neurons, and affects synaptic transmission. Here we report for the first time that the Reelin signaling pathway promotes the development of postsynaptic structures such as dendritic spines in hippocampal pyramidal neurons. Our data underscore the importance of Reelin as a factor that promotes the maturation of target neuronal populations and the development of excitatory circuits in the postnatal hippocampus. These findings may have implications for understanding the origin of cognitive disorders associated with Reelin deficiency.