Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD
Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD
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DOI：
10.1359/jbmr.070213
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发表时间：
2007-05-01
影响因子：
6.2
通讯作者：
Specker, Bonny L.
中科院分区：
文献类型：
--
作者：
Havill, Lorena M.;Mahaney, Michael C.;Specker, Bonny L.
对710名8-85岁的相互关联的个体的骨数据进行定量遗传分析，发现BMC、骨面积、面积和体积BMD的遗传性估计值在骨部位之间存在差异。活动水平，特别是中等强度和剧烈活动的时间，对骨骼有显著影响。在某些情况下，这些影响是年龄和性别specific.Introduction：遗传和环境因素在决定BMC，骨大小和BMD中发挥着复杂的作用。本研究评估了骨测量的遗传性，其特点是年龄，性别和身体活动对骨的影响，并测试了年龄和性别特异性骨activity.Materials和方法的影响：骨大小和面积和体积密度（aBMD和vBMD，分别）的措施，获得DXA和pQCT 710个相关的个人（466名妇女）8-85岁。活动测量包括中度+剧烈活动的时间百分比（%ModVig）、每天爬楼梯和每天步行英里数。定量遗传分析进行建模活动和协变量对骨outcome.Results的影响：占年龄，性别和活动水平的影响，基因解释40-62%的残余变异BMC和BMD和27-75%的骨大小（所有p < 0.001）。女性股骨颈（FN）、髋关节和脊柱aBMD随年龄增长的下降幅度大于男性（年龄与性别的相互作用;所有p
Quantitative genetic analyses of bone data for 710 inter-related individuals 8-85 yr of age found high heritability estimates for BMC, bone area, and areal and volumetric BMD that varied across bone sites. Activity levels, especially time in moderate plus vigorous activity, had notable effects on bone. In some cases, these effects were age and sex specific.Introduction: Genetic and environmental factors play a complex role in determining BMC, bone size, and BMD. This study assessed the heritability of bone measures; characterized the effects of age, sex, and physical activity on bone; and tested for age- and sex-specific bone effects of activity.Materials and Methods: Measures of bone size and areal and volumetric density (aBMD and vBMD, respectively) were obtained by DXA and pQCT on 710 related individuals (466 women) 8-85 yr of age. Measures of activity included percent time in moderate + vigorous activity (%ModVig), stair flights climbed per day, and miles walked per day. Quantitative genetic analyses were conducted to model the effects of activity and covariates on bone outcomes.Results: Accounting for effects of age, sex, and activity levels, genes explained 40-62% of the residual variation in BMC and BMD and 27-75% in bone size (all p < 0.001). Decline in femoral neck (FN), hip, and spine aBMD with advancing age was greater among women than men (age-by-sex interaction; all p