A subcortical inhibitory signal for behavioral arrest in the thalamus.
A subcortical inhibitory signal for behavioral arrest in the thalamus.
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DOI：
10.1038/nn.3951
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发表时间：
2015-04
影响因子：
25
通讯作者：
Acsády L
中科院分区：
文献类型：
--
作者：
Giber K;Diana MA;Plattner V;Dugué GP;Bokor H;Rousseau CV;Maglóczky Z;Havas L;Hangya B;Wildner H;Zeilhofer HU;Dieudonné S;Acsády L
行为的组织需要脑干和前脑活动的快速协调。这些地区之间有效沟通的确切机制目前尚不清楚。板内丘脑（IL）可能是连接脑干和前脑关键区域的中枢。在这里，我们发现，GABA能/甘氨酸能纤维从脑桥网状结构（PRF）的脑干上升引起快速和可靠的抑制IL丘脑通过大，多突触终端。这种抑制通过在单个突触表达的不均匀GABA能/甘氨酸能受体比率进行微调。光遗传激活的PRF轴突在IL的自由移动的小鼠导致行为逮捕和短暂中断清醒的皮质活动。在人IL中也发现了具有可比形态学特征的传入系统。这些数据揭示了一个进化上保守的上升系统，通过快速和强大的突触抑制IL丘脑门前脑活动。
Organization of behavior requires rapid coordination of brainstem and forebrain activity. The exact mechanisms of effective communication between these regions are presently unclear. The intralaminar thalamus (IL) probably serves as a central hub in this circuit by connecting the critical brainstem and forebrain areas. Here we found that GABAergic/glycinergic fibers ascending from the pontine reticular formation (PRF) of the brainstem evoke fast and reliable inhibition in the IL thalamus via large, multisynaptic terminals. This inhibition was fine-tuned through heterogeneous GABAergic/glycinergic receptor ratios expressed at individual synapses. Optogenetic activation of PRF axons in the IL of freely moving mice led to behavioral arrest and transient interruption of awake cortical activity. An afferent system with comparable morphological features was also found in the human IL. These data reveal an evolutionarily conserved ascending system which gates forebrain activity through fast and powerful synaptic inhibition of the IL thalamus.