Timeline - Chemotherapy and the war on cancer
Timeline - Chemotherapy and the war on cancer
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DOI：
10.1038/nrc1529
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发表时间：
2005-01-01
影响因子：
78.5
通讯作者：
Roberts, TG
中科院分区：
文献类型：
--
作者：
Chabner, BA;Roberts, TG
化疗的时代开始于20世纪40年代，首次使用氮芥和抗叶酸药物。从那时起，癌症药物的开发已经从一个低预算、政府支持的研究工作转变为一个高风险、数十亿美元的产业。靶向治疗革命已经到来，但早期研究人员发现的化疗原则和局限性仍然适用。本文记载了现代化疗的历史，并确定了下一代研究人员面临的挑战。
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development since then has transformed from a low-budget, government-supported research effort to a high-stakes, multi-billion dollar industry. The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. This article chronicles the history of modern chemotherapy and identifies remaining challenges for the next generation of researchers.