Fifty-year trends in serial body mass index during adolescence in girls: the Fels Longitudinal Study
Fifty-year trends in serial body mass index during adolescence in girls: the Fels Longitudinal Study
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DOI：
10.1093/ajcn/80.2.441
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发表时间：
2004-08-01
影响因子：
7.1
通讯作者：
Siervogel, RM
中科院分区：
文献类型：
--
作者：
Demerath, EW;Li, JR;Siervogel, RM
背景：最近有报道称美国女孩月经初潮年龄下降。虽然最近的下降可能是由于儿童肥胖的同时增加，但很少有关于生长和发育的纵向研究专门针对生长、肥胖和初潮年龄之间的时间关系。目的是同时检查出生队列的影响，（长期趋势）和成熟率（初潮年龄）对青春期女孩体重指数（BMI）增加的时间和模式的影响。设计：我们应用混合效应多项式模型的连续BMI数据，从初潮前6年到初潮后6年，从211名女孩参加了费尔斯纵向研究。我们检验了出生队列的影响（定义为1929 - 1946年、1947-1964年和1965-1983年出生的女孩）和初潮年龄（定义为小于或等于11.9岁：12.0-13.1岁，大于或等于13.2岁）对青春期BMI的大小和速度的影响。1965年以后出生的女孩的BMI和BMI速度显著大于较早出生的女孩，尽管月经初潮的平均年龄稳定。虽然女孩初潮早期往往有显着较高的BMI比女孩平均或月经初潮后期，这些差异并没有出现，直到月经初潮后。结论：这些数据表明，相对重量的增加是一个后果。而不是初潮年龄的决定因素，BMI和初潮平均年龄的长期变化可能是独立的现象。
Background: A decline in the age at menarche was recently reported for US girls. Although it is possible that this recent drop stems from the concurrent increase in childhood obesity, few longitudinal studies of growth and development have been undertaken to specifically address the temporal relation between growth, adiposity, and the age at menarche.Objective: The objective was to simultaneously examine the effects of birth cohort (secular trend) and rate of maturation (age at menarche) on the timing and pattern of increases in body mass index (BMI) during adolescence in girls.Design: We applied mixed-effects polynomial models to serial BMI data, spanning from 6 y before menarche to 6 y after menarche, obtained from 211 girls enrolled in the Fels Longitudinal Study. We examined the effects of birth cohort (defined as girls born 19291946 1947-1964, and 1965-1983) and age at menarche (defined as less than or equal to11.9 y: 12.0-13.1 y, and greater than or equal to13.2 y) on the magnitude and velocity of BMI during adolescence.Results: BMI and BMI velocity in girls born after 1965 were significantly greater than those of girls of earlier birth cohorts, despite stability in the mean age at menarche. Although girls with early menarche tended to have significantly higher BMIs than did girls with average or later menarche, these differences did not emerge until after menarche.Conclusion: These data suggest that increases in relative weight are a consequence. rather than a determinant, of the age at menarche and that secular changes in BMI and in the mean age at menarche could be independent phenomena.