Schistosoma japonicumSjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
Schistosoma japonicumSjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
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DOI：
10.3389/fimmu.2020.01767
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发表时间：
2020-08-21
影响因子：
7.3
通讯作者：
Wang, Zhaojun
中科院分区：
文献类型：
--
作者：
Wu, Chenyun;Du, Xinyue;Wang, Zhaojun
Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted fromSchistosoma japonicumeggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to activation of the NF-kappa B signaling pathway, an increase in the generation of reactive oxygen species, and production of the pro-inflammatory cytokines IL-6 and TNF-alpha. Using a mouse model of colorectal cancer, we demonstrate that intraperitoneal injection of SjE16.7 promotes colorectal cancer progression along with systemic myeloid cell accumulation. Thus, our results identify a new helminth antigen contributing to tumor development in the mammalian host.
