A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
A first case of meningitis/encephalitis associated with SARS-Coronavirus-2
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DOI：
10.1016/j.ijid.2020.03.062
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发表时间：
2020-05-01
影响因子：
8.4
通讯作者：
Shimada, Shinji
中科院分区：
文献类型：
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作者：
Moriguchi, Takeshi;Harii, Norikazu;Shimada, Shinji
新型冠状病毒（SARS-Coronavirus-2：SARS-CoV-2）在中国武汉出现，已迅速蔓延到多个国家。我们报告了第一例与SARS-CoV-2相关的脑膜炎病例，由于抽搐伴无意识而被救护车送来。他从未去过任何外国。他感到全身疲乏和发热（第1天）。他在附近看了两次医生（第2天和第5天），医生给他开了Laninamivir和退烧药。他立即被救护车送往该医院（第9天）。在紧急转运过程中，他出现了持续约一分钟的短暂全身性癫痫发作。他有明显的颈部僵硬。在鼻咽拭子中未检测到特异性SARS-CoV-2 RNA，但在CSF中检测到。血清标本中未检出抗HSV-1和水痘-带状疱疹IgM抗体。脑部MRI显示右侧脑室壁沿着高信号，右侧内侧颞叶和海马高信号改变，提示SARS-CoV-2脑膜炎的可能性。该病例提醒医生注意有CNS症状的患者。(C)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。
Novel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with SARS-CoV-2 who was brought in by ambulance due to a convulsion accompanied by unconsciousness. He had never been to any foreign countries. He felt generalized fatigue and fever(day 1). He saw doctors near by twice (day 2 and 5) and was prescribed Laninamivir and antipyretic agents, His family visited his home and found that he was unconsciousness and lying on the floor in his vomit. He was immediately transported to this hospital by ambulance (day 9). Under emergency transport, he had transient generalized seizures that lasted about a minute. He had obvious neck stiffness. The specific SARS-CoV-2 RNA was not detected in the nasopharyngeal swab but was detected in a CSF. Anti-HSV 1 and varicella-zoster IgM antibodies were not detected in serum samples. A brain MRI showed hyperintensity along the wall of right lateral ventricle and hyperintense signal changes in the right mesial temporal lobe and hippocampus, suggesting the possibility of SARS-CoV-2 meningitis. This case warns the physicians of patients who have CNS symptoms. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.