Plasmapheresis and immunosuppressive therapy. Effect on levels of intercellular antibodies in pemphigus vulgaris.
Plasmapheresis and immunosuppressive therapy. Effect on levels of intercellular antibodies in pemphigus vulgaris.
复制标题
血浆置换和免疫抑制治疗。
DOI：
10.1001/archderm.1979.04010060036025
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发表时间：
1979
影响因子：
--
通讯作者：
J. Bystryn
中科院分区：
文献类型：
--
作者：
R. Auerbach;J. Bystryn
本文报告一位寻常型天疱疮病人，因类固醇治疗有严重副作用，而接受血浆置换治疗。在六周内进行了八次血浆置换。每种方法都可使血清细胞间抗体水平降低50%至87%。细胞间抗体水平的反弹通常在其耗尽后发生，但可以通过给予环磷酰胺最小化或完全抑制。经过六周的治疗，临床症状大大改善，细胞间抗体水平从5，120滴度降至160。由于患者同时接受低剂量泼尼松和环磷酰胺间歇治疗，因此不可能将这些改善具体归因于血浆置换。
A patient with pemphigus vulgaris and serious side effects of steroid therapy was treated by exchange plasmapheresis. Eight plasmaphereses were performed over six weeks. Each procedure reduced the serum level of intercellular antibodies by 50% to 87%. A rebound in levels of intercellular antibodies usually followed their depletion but could be minimized or completely suppressed by administration of cyclophosphamide. After six weeks of therapy, clinical symptoms had greatly improved and intercellular antibody levels had decreased from a titer of 5,120 to 160. It is not possible to ascribe these improvements specifically to plasmapheresis since the patient was concurrently receiving low doses of prednisone and intermittent treatment with cyclophosphamide.