Improved Procedure for Preparation of Abiraterone Acetate
Improved Procedure for Preparation of Abiraterone Acetate
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DOI：
10.1021/op500044p
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发表时间：
2014-04-01
影响因子：
3.4
通讯作者：
Joseph, Sony
中科院分区：
文献类型：
--
作者：
Madhra, Mukesh Kumar;Sriram, Hari Mohan;Joseph, Sony
描述了制备醋酸阿比特龙的改进方法。本发明的方法突出了减少的反应时间，用酸碱处理分离而不涉及柱色谱法，多次结晶，并且适合于大规模合成。
An improved procedure for the preparation of abiraterone acetate is described. The present process highlights reduced reaction time, isolation with acid-base treatment without involving column chromatography, multiple crystallization and is amenable to large-scale synthesis.