Morphogenetic and molecular correlates of teratogenesis in the amphibian embryo.
Morphogenetic and molecular correlates of teratogenesis in the amphibian embryo.
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两栖动物胚胎畸形发生的形态发生和分子相关性。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
S. Brennan
中科院分区：
文献类型：
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作者：
S. Brennan
在试图开发一个系统来研究致畸的分子机制，检查致畸剂（二甲基亚砜）的影响，在两栖动物非洲爪蟾胚胎发育的分子和形态学方面已经进行。特征形态效应，发生在受精后7 - 16小时（即，原肠胚形成）。原肠胚形成的延迟伴随着已知在正常发育的原肠胚形成期间活跃的几个基因的转录调节的变化。还观察到后来的形态学效应，这些效应可能是原肠胚形成过程中发生的变化的结果。因此，已检测到对致畸剂的分子反应，并观察到对致畸剂的分子和形态学反应之间的相关性。这些发现首次证明了致畸剂对特定基因转录的影响，并引发了一种或多种分子事件介导致畸作用的猜测。他们进一步表明，两栖动物系统可能有助于研究致畸剂的早期分子反应。
In attempting to develop a system to study molecular mechanisms of teratogenesis, examination of the effects of a teratogen (dimethyl sulfoxide) on both molecular and morphological aspects of embryonic development in the amphibian Xenopus laevis has been conducted. Characteristic morphological effects, which occur during the period from 7 to 16 hours after fertilization (i.e., gastrulation) are noted. Delays in gastrulation are accompanied by changes in the regulation of transcription of several genes known to be active during gastrulation in normal development. Later morphological effects are also observed, and these probably arise as a consequence of the changes occurring during gastrulation. Thus, molecular responses to a teratogen have been detected, and a correlation between molecular and morphological responses to a teratogen is observed. These findings represent the first demonstration of the effects of a teratogen on the transcription of specific genes, and invite speculation that one or more molecular events mediate teratogenesis. They further suggest that the amphibian system may be useful for studying early molecular responses to teratogens.
DOI：
10.1146/annurev.cb.02.110186.001221
发表时间：
1986
期刊：
Annual review of cell biology
影响因子：
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作者：
J. Gerhart;R. Keller
通讯作者：
J. Gerhart;R. Keller
非洲爪蟾卵的皮质旋转：胚胎背侧发育前后模式的后果。
DOI：
10.1242/dev.107.supplement.37
发表时间：
1989
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Gerhart,J;Danilchik,M;Doniach,T;Roberts,S;Rowning,B;Stewart,R
通讯作者：
Stewart,R