The cell as a material
The cell as a material
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DOI：
10.1016/j.ceb.2006.12.002
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发表时间：
2007-02-01
影响因子：
7.5
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
--
作者：
Kasza, Karen E.;Rowat, Amy C.;Weitz, David A.
为了阐明细胞在其所属组织中的动态和功能作用，必须了解其材料特性。细胞是一种粘弹性材料，具有非常不寻常的特性。细胞力学行为的测量开始探索组成成分对细胞力学的贡献。重构的细胞骨架蛋白质网络已被证明可以模拟细胞力学特性的许多方面，为细胞行为的起源提供了新的见解。这些网络是高度非线性的，弹性模量敏感地依赖于所施加的应力。理论可以解释一些测量的属性，但一个完整的模型仍然难以捉摸。
To elucidate the dynamic and functional role of a cell within the tissue it belongs to, it is essential to understand its material properties. The cell is a viscoelastic material with highly unusual properties. Measurements of the mechanical behavior of cells are beginning to probe the contribution of constituent components to cell mechanics. Reconstituted cytoskeletal protein networks have been shown to mimic many aspects of the mechanical properties of cells, providing new insight into the origin of cellular behavior. These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive.