Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older US women
Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older US women
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DOI：
10.2337/diacare.28.12.2926
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发表时间：
2005-12-01
期刊：
影响因子：
16.2
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Liu, S;Song, Y;Ridker, PM
目的-检查是否以及在何种程度上钙和维生素D的摄入量与代谢综合征在中年或老年women.RESEARCH设计和方法-我们分析了10，066名妇女年龄>= 45岁参与妇女健康研究的数据，这些妇女没有心血管疾病，癌症或糖尿病，并且从未使用过绝经后激素。我们使用多元逻辑回归模型来估计多变量比值比（OR）和95%CI，比较不同的钙和维生素D饮食摄入水平。结果-在年龄和热量调整分析中，总钙、膳食钙和补充钙的摄入量较高与代谢综合征的患病率显著负相关。在进一步校正吸烟状况、运动、饮酒、多种维生素使用和父母60岁以前心肌梗死史后，总钙摄入量增加五分位数的代谢综合征OR为1.00（参比品）、0.82（95% CI 0.70-0.97）、0.84（0.71-0.99）、0.70（0.59-0.83）和0.64（0.54-0.77）（趋势P
OBJECTIVE - To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women.RESEARCH DESIGN AND METHODS - We analyzed data from 10,066 women aged >= 45 years participating in the Women's Health Study who were free of cardiovascular disease, cancer, or diabetes and who never used postmenopausal hormones. We used multiple logistic regression models to estimate multivariable odds ratios (ORs) and 95% CIs comparing different dietary intake levels of calcium and vitamin D.RESULTS - in age- and calorie-adjusted analyses, higher intakes of total, dietary, and supplemental calcium were significantly and inversely associated with the prevalence of metabolic syndrome. After further adjusting for smoking status, exercise, alcohol intake, multivitamin use, and parental history of myocardial infarction before age 60 years, the ORs of having the metabolic syndrome for increasing quintiles of total calcium intake were 1.00 (reference), 0.82 (95% CI 0.70-0.97), 0.84 (0.71-0.99), 0.70 (0.59-0.83), and 0.64 (0.54-0.77) (P for trend