LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population
LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population
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LRRK2 A419V 变异是亚洲人群帕金森病的危险因素
DOI：
10.1016/j.neurobiolaging.2015.07.012
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发表时间：
2015-10-01
影响因子：
4.2
通讯作者：
Guo, Ji-feng
中科院分区：
文献类型：
--
作者：
Li, Kai;Tang, Bei-sha;Guo, Ji-feng
近年来，有报道称LRRK 2 A419 V（rs34594498）与亚洲人群帕金森病（Parkinson's disease，PD）相关，但结论尚不明确。我们进行了一项病例对照研究，以确定中国人群中A419 V与PD之间的潜在关联。500例PD患者和574名健康对照进行了基因分型。我们的结果显示，PD患者中A419 V的频率显著高于对照组（p = 0.025，比值比[OR] = 2.57，95%置信区间[CI] [1.13-5.86]），尤其是在早发性PD中（p = 0.027，OR = 10.40，95% CI [1.31-82.89]）。携带A419 V的PD患者的最低精神状态检查评分低于未携带A419 V的PD患者（p = 0.04）。我们还对A419 V进行了荟萃分析。在亚洲人群中，PD患者中A419 V的检出频率显著高于对照组：Z = 2.47，p = 0.01，OR = 2.11，95% CI [1.17-3.82]。当仅考虑中国人群时，差异更明显，Z = 3.41，p = 0.0007，OR = 2.07，95% CI [1.36-3.14]。结果表明，LRRK 2 A419 V似乎是亚洲人PD的危险因素，尤其是在早发患者中。最后，以亚洲年轻或认知障碍PD患者为中心的更大样本更适合进一步确认。(C)2015 Elsevier Inc. All rights reserved.
Recently, LRRK2 A419V (rs34594498) was reported associating with Parkinson's disease (PD) in Asian population; yet the conclusion is still unobvious. We conducted a case-control study to determine the potential associations between A419V and PD in Chinese population. Five hundred PD patients and 574 health controls were genotyped. Our results showed, A419V has a significantly higher frequency among PD patients than the controls (p = 0.025, odds ratio [OR] = 2.57, 95% confidence interval [CI] [1.13-5.86]), especially in early-onset PD (p = 0.027, OR = 10.40, 95% CI [1.31-82.89]). And PD patients who carried A419V have a lower Minimum-Mental State Examination scores than PD patients who did not (p = 0.04). We also conducted a meta-analysis on A419V. In Asian population, A419V was detected at a significantly higher frequency among PD patients in contrast to controls: Z = 2.47, p = 0.01, OR = 2.11, 95% CI [1.17-3.82]. When only considering the Chinese population, the difference was more obvious with Z = 3.41, p = 0.0007, OR = 2.07, 95% CI [1.36-3.14]. The results suggest LRRK2 A419V appears to be a risk factor for PD in Asian, especially in early-onset patients. Finally, larger sample with centering on young or cognitive impairment PD patients in Asian would be preferable for further confirmation. (C) 2015 Elsevier Inc. All rights reserved.