Protection Against Herpes Virus and Encephalomyocarditis Virus Encephalitis with a Double-Stranded RNA Inducer of Interferon
Protection Against Herpes Virus and Encephalomyocarditis Virus Encephalitis with a Double-Stranded RNA Inducer of Interferon
复制标题
使用干扰素双链 RNA 诱导剂预防疱疹病毒和脑心肌炎病毒脑炎
DOI：
10.3181/00379727-133-34544
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发表时间：
1970
影响因子：
--
通讯作者：
S. Baron
中科院分区：
文献类型：
--
作者：
L. W. Catalano;S. Baron
Summary The interferon sensitivities of intracerebrally administered HSV (VR3 strain) and EMCV (r+ strain) were determined in mice with a potent inducer of circulating interferon, polyinosinic·polycytidylic ribonucleic acid (In·Cn). With the treatment as described, delay in mortality occurred at most challenge doses of HSV and EMCV. Significant delay in mortality and increased survival was obtained with 1000 and 100 TCID50 of EMCV, whereas, significant protection was achieved for only 1 TCID50 of HSV with mortality decreasing to about 12–20% as compared to 52–58% in the controls. The data show that sufficient interferon can be induced in the mouse with In·Cn to significantly alter intracerebral infection with HSV and EMCV. The protective effect of In·Cn against intracerebral infection of mice with HSV and EMCV was equal only when the challenge dose of each was sufficiently low. The protective effect against HSV was lost with increasing virus doses of virus whereas the protective effect against EMCV decreased only slightly with increasing virus dose.
