Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions
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DOI：
10.1016/j.cellimm.2011.11.002
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Min, Booki
中科院分区：
文献类型：
--
作者：
Do, Jeong-su;Foucras, Gilles;Min, Booki
在淋巴细胞减少的受者体内，初始 T 细胞会经历由稳态机制诱导的增殖。早期研究表明共生抗原在诱导增殖中发挥关键作用。然而，内源性自身抗原在此过程中的相对贡献尚未得到正式研究。在这项研究中，我们利用一种药物抑制剂来阻止 T 细胞从淋巴组织、抗生素和无菌动物中流出，以检查共生抗原和自身抗原的作用。结果表明，淋巴细胞减少条件下的 T 细胞增殖是由外源共生抗原和内源自身抗原触发的异质过程。 (C) 2011 Elsevier Inc. 保留所有权利。
Within lymphopenic recipients, naive T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens. (C) 2011 Elsevier Inc. All rights reserved.