Reduced regional brain glucose metabolism assessed by positron emission tomography in electrodermal nonresponder schizophrenics: a pilot study.
Reduced regional brain glucose metabolism assessed by positron emission tomography in electrodermal nonresponder schizophrenics: a pilot study.
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通过正电子发射断层扫描评估皮电无反应精神分裂症患者的区域脑葡萄糖代谢减少：一项试点研究。
DOI：
10.1037//0021-843x.102.1.39
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发表时间：
1993
影响因子：
4.6
通讯作者：
Nuechterlein,KH
中科院分区：
文献类型：
--
作者：
Hazlett,EA;Dawson,ME;Buchsbaum,MS;Nuechterlein,KH
这项初步研究考察了在连续性能测试中，通过正电子发射断层扫描评估的精神分裂症患者的皮肤电无反应亚组和反应亚组在区域脑代谢方面是否存在差异。与正常对照组（n= 6）和反应性精神分裂症患者（n= 3）相比，无反应性精神分裂症患者（n= 3）整个大脑的代谢率降低了约20%。无反应的精神分裂症患者在额外侧和内侧、丘脑和海马区的绝对代谢率往往低于反应者。无反应者在内侧额叶区、海马区以及右侧杏仁核的相对代谢率也明显较低。这些数据表明，精神分裂症患者的皮电亚群虽然参与了皮电活动，但在区域特异性脑代谢过程和广义脑代谢过程中存在差异。
This pilot study examined whether electrodermal nonresponder and responder subgroups of schizophrenic patients differ in regional brain metabolism assessed by Positron Emission Tomography during a continuous performance test. In comparison to both normal controls (n= 6) and responder schizophrenics (n= 3), the nonresponder schizophrenics (n= 3) showed about a 20% reduction in metabolic rate across the entire brain. Nonresponder schizophrenics tended to have lower absolute metabolic rates than responders in lateral and medial frontal, thalamic, and hippocampal areas. Nonresponders also had significantly lower relative metabolic rates in medial frontal and hippocampal areas as well as the right amygdala. These data suggest that electrodermal subgroups of schizophrenics differ in both regionally specific brain metabolic processes though to be involved in electrodermal activity and in generalized brain metabolism.