Correlation Between Heat or Cold Syndrome and Cytokine, and Laboratory Index in Women with Early Rheumatoid Arthritis
Correlation Between Heat or Cold Syndrome and Cytokine, and Laboratory Index in Women with Early Rheumatoid Arthritis
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发表时间：
2006
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通讯作者：
L. Ai-ping
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作者：
L. Ai-ping
目的：探讨细胞因子（TNF-α、IL-10、IL-8）、临床炎症指标（ESR、CRP）和临床免疫指标（IgA、IgM、IgG、RF、C3）对女性早期类风湿关节炎（RA）热寒证的诊断价值。方法：将70例女性RA患者分为热证型和寒证型。采集血样检测细胞因子、临床炎症指标、临床免疫指标等指标。结果采用双向分类方差分析。结果：除CRP外，热寒证组各细胞因子（TNF-α、IL-10、IL-8）、临床炎症指标（ESR）、免疫指标（IgA、IgG、IgM、RF、C3）的表达差异均无统计学意义。结论：女性RA热证患者CRP表达高于寒证患者，提示CRP对RA热寒证有潜在的诊断价值。
Objective: To evaluate the diagnositic value of the cytokines (TNF-α, IL-10, IL-8), clinical inflammatory indexes (ESR, CRP), and clinical immune indexes (IgA, IgM, IgG, RF, C3) on heat or cold syndrome in female patients with rheumatoid arthritis(RA) of early stage. Methods: 70 female RA patients were divided into heat and cold syndrome type. The blood samples were collected and detected for the following indexes such as cytokines, clinical inflammatory indexes, clinical immune indexes. The results were analyzed by two-way classification ANOVA. Results: Except CRP, the expression of cytokine (TNF-α, IL-10, IL-8), clinical inflammatory indexes (ESR), immune indexes (IgA, IgG, IgM, RF, C3)of subjects with heat and cold syndrome had no significant difference. Conclusion: Female RA patients with heat syndrome have higher expression of CRP than those with cold syndrome, which indicates that CRP has potential diagnositic value to heat and cold syndrome in RA.