CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice
CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice
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DOI：
10.1016/j.bbrep.2020.100791
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发表时间：
2020-08
影响因子：
2.7
通讯作者：
Yoshimi Uchida;G. Nishitai;Kenta Kikuchi;Takumi Shibuya;K. Asano;Masato Tanaka
中科院分区：
文献类型：
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作者：
Yoshimi Uchida;G. Nishitai;Kenta Kikuchi;Takumi Shibuya;K. Asano;Masato Tanaka
脓毒症是由感染引起的炎症反应失调引起的危及生命的多器官功能障碍。如果不及时诊断和治疗，它仍然是感染死亡的主要原因。因此，需要更好地了解解决炎症的机制。单核细胞和巨噬细胞不仅在炎症的诱导中而且在炎症的抑制中起关键作用。然而，在脓毒症期间调节高炎症状态的组织驻留巨噬细胞亚群尚未被探索。在这里，我们表明，CD 204+单核细胞和/或巨噬细胞拯救小鼠从内毒素诱导的脓毒性休克。血清和组织促炎细胞因子水平显着上调，在这些细胞的情况下。这项研究提供了证据表明，CD 204+单核细胞和/或巨噬细胞通过抑制促炎细胞因子的产生来改善感染性休克。
Sepsis is defined as a life-threatening multiorgan dysfunction caused by dysregulated inflammatory response to infection. It remains the primary cause of death from infection if not diagnosed and treated promptly. Therefore, a better understanding of the mechanism for resolving inflammation is needed. Monocytes and macrophages play a pivotal role not only in the induction but also in the suppression of inflammation. However, a tissue-resident macrophage subset that regulates a hyperinflammatory state during sepsis has not been explored. Here we show that CD204+monocytes and/or macrophages rescued mice from endotoxin-induced septic shock. Serum and tissue proinflammatory cytokine levels were significantly upregulated in the absence of these cells. This study provided evidence that CD204+monocytes and/or macrophages ameliorate septic shock by suppressing proinflammatory cytokine production.