Effects of superoxide dismutase on lipopolysaccharide-stressed mice and alteration of lung enzyme levels by endotoxin.
Effects of superoxide dismutase on lipopolysaccharide-stressed mice and alteration of lung enzyme levels by endotoxin.
复制标题
超氧化物歧化酶对脂多糖应激小鼠的影响以及内毒素对肺酶水平的改变。
DOI：
10.1016/0041-008x(81)90334-3
复制
发表时间：
1981
影响因子：
3.8
通讯作者：
B. Gray
中科院分区：
文献类型：
--
作者：
B. Gray
超氧化物歧化酶（SOD）注射到小鼠之前，脂多糖（内毒素）的挑战，提高小鼠的生存。然而，小鼠预防性给予足够高于或低于最佳浓度的SOD并没有得到保护。用内毒素攻击的小鼠肺提取物中谷胱甘肽过氧化物酶和过氧化氢酶的水平没有明显变化。内毒素攻击后1小时内，肺组织中SOD酶比活性下降约50%。肺超氧化物歧化酶比活性的降低随着内毒素剂量的增加而增加。内毒素攻击后小鼠肺中超氧化物歧化酶比活性的降低可能是由于需要升高的O2−浓度。超氧阴离子是小鼠肺中发现的至少一种内毒素诱导酶的必需底物。
Superoxide dismutase (SOD) injected into mice prior to lipopolysaccharide (endotoxin) challenge enhanced mouse survival. However, mice administered prophylactic SOD at levels sufficiently above or below the optimum concentration were not protected. The levels of glutathione peroxidase and catalase in extracts from lungs of mice challenged with endotoxin did not change appreciably. SOD enzyme specifc activity in lung extracts was reduced about 50% within 1 hr of endotoxin challenge. The reduction in lung superoxide dismutase specific activity increased with increasing endotoxin dose. Reduction of superoxide dismutase specific activity in mouse lung following endotoxin challenge may be necessitated by a requirement for an elevated O2−concentration. Superoxide anion is a required substrate for at least one endotoxininducible enzyme found in mouse lung.