Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell lung cancer patient with poor performance status.
Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell lung cancer patient with poor performance status.
复制标题
对体力状态不佳的非小细胞肺癌患者进行多学科治疗后的长期结果。
作者：
T. Nagano;Y. Kotani;Kazuyuki Kobayashi;Y. Hatakeyama;Suya Hori;Daisuke Kasai;Y. Funada;H. Nishimura;T. Kondoh;Y. Nishimura
本研究描述了一例60岁的日本男性，组织学诊断为肺腺癌，携带表皮生长因子受体L858R突变。他用吉非替尼成功地治疗了他，但最终发展为脑膜轻脑癌。他接受脑室-腹膜分流治疗脑积水，接受厄洛替尼代替吉非替尼，同时进行全脑放疗；这导致他的症状和行为状态从4个显著改善到1个，在开始厄洛替尼治疗后，他存活了长达13.6个月。这种多学科方法在提高生存率和改善生活质量方面可能特别有用。
The present study describes a case of a 60-year-old Japanese man who was histologically diagnosed with lung adenocarcinoma harboring L858R mutation of epidermal growth factor receptor. He was successfully treated with gefitinib, but eventually developed leptomeningeal carcinomatosis. He underwent ventriculoperitoneal shunting for hydrocephalus and received erlotinib in place of gefitinib with concurrent whole brain radiotherapy; this resulted in dramatic improvement in his symptoms and performance status from four to one and he survived for as long as 13.6 months after the initiation of erlotinib therapy. This multidisciplinary approach may be particularly useful in terms of increasing survival and improving quality of life.
影响因子：
45.3
作者：
Jackman, David M.;Holmes, Alison J.;Johnson, Bruce E.
通讯作者：
Johnson, Bruce E.