Temporal Associations of Plasma Levels of the Secreted Phospholipase A 2 Family and Mortality in Severe COVID-19.
Temporal Associations of Plasma Levels of the Secreted Phospholipase A 2 Family and Mortality in Severe COVID-19.
复制标题
分泌型磷脂酶 A 2 家族血浆水平与严重 COVID-19 死亡率的时间关联。
DOI：
10.1101/2022.11.21.22282595
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Chilton,FloydH
中科院分区：
文献类型：
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作者：
Lu,Eric;Hara,Aki;Sun,Shudong;Hallmark,Brian;Snider,JustinM;Seeds,MichaelC;Watkins,JosephC;McCall,CharlesE;Zhang,HaoHelen;Yao,Guang;Chilton,FloydH
先前的研究表明，IIA组分泌的磷脂酶A2（sPLA2 - IIA）在致命的COVID - 19疾病中发挥作用并预测其预后。目前的研究重新分析了纵向蛋白质组学数据集，以确定214名ICU患者中spla2亚型家族中几个成员的水平与COVID - 19严重程度之间的时间关系。6种分泌的pla2亚型sPLA2 - IIA、sPLA2 - V、sPLA2 - X、sPLA2 - IB、sPLA2 - IIC和sPLA2 - XVI的水平在死亡患者的前7个ICU天内升高，而在幸存者中则在同一时间内降低。相反，sPLA2 - IID和sPLA2 - XIIB水平在7天内呈现相反的模式，表明这两种亚型具有保护作用。此外，决策树模型表明sPLA2 - IIA在预测患者预后方面优于排名靠前的细胞因子和趋化因子。总之，蛋白质组学分析揭示了spla2的时间模式，反映了spla2亚型在严重COVID - 19疾病中的关键作用。
Previous research suggests that group IIA‐secreted phospholipase A2(sPLA2‐IIA) plays a role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA2isoforms and the severity of COVID‐19 in 214 ICU patients. The levels of six secreted PLA2isoforms, sPLA2‐IIA, sPLA2‐V, sPLA2‐X, sPLA2‐IB, sPLA2‐IIC, and sPLA2‐XVI, increased over the first 7 ICU days in those who succumbed to the disease but attenuated over the same time period in survivors. In contrast, a reversed pattern in sPLA2‐IID and sPLA2‐XIIB levels over 7 days suggests a protective role of these two isoforms. Furthermore, decision tree models demonstrated that sPLA2‐IIA outperformed top‐ranked cytokines and chemokines as a predictor of patient outcome. Taken together, proteomic analysis revealed temporal sPLA2patterns that reflect the critical roles of sPLA2isoforms in severe COVID‐19 disease.