Comparative Study of Direct Immunofluorescence in Discoid Lupus Erythematosus and Bullous Pemphigoid
Comparative Study of Direct Immunofluorescence in Discoid Lupus Erythematosus and Bullous Pemphigoid
复制标题
盘状红斑狼疮与大疱性类天疱疮直接免疫荧光的比较研究
DOI：
10.1097/dad.0000000000000387
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
T. Nakama
中科院分区：
文献类型：
--
作者：
C. Ohata;B. Ohyama;H. Nagata;M. Furumura;T. Nakama
摘要：红斑狼疮和大疱性类天疱疮(BP)的表皮基底膜均有免疫反应物存在。据我们所知，盘状红斑狼疮(DLE)与BP的直接免疫荧光(DIF)检测尚无对比研究。作者对9例DLE患者(男2例，女7例)和29例BP患者(男11例，女18例)皮损皮肤DIF进行了研究，以揭示这两种疾病之间的差异。BP组表皮基底膜区(BMZ)的免疫球蛋白G沉积频率显著高于DLE组，而DLE组表皮和毛囊BMZ的IgA和IgM沉积频率明显高于BP组。此外，DLE组表皮和毛囊BMZ中阳性免疫反应物的平均数量明显多于BP组。平均而言，≥-3免疫反应物在DLE的表皮和毛囊BMZ处可见，而BP的⩽-2.5免疫反应物在BP中可见。DIF可能有助于这两种疾病的鉴别。
Abstract:Immunoreactants are found in the epidermal basement membrane in both lupus erythematosus and bullous pemphigoid (BP). To our knowledge, there are no comparative studies on direct immunofluorescence (DIF) of discoid lupus erythematosus (DLE) and BP. The authors studied DIF of lesional skins in 9 patients (2 males and 7 females) with DLE and 29 patients (11 males and 18 females) with BP to disclose the difference between these 2 diseases. IgG deposition was significantly more frequent at the epidermal basement membrane zone (BMZ) in the BP group than in the DLE group; however, IgA and IgM depositions were significantly more frequent at both the epidermal and follicular BMZs in the DLE group than in the BP group. In addition, the mean number of positive immunoreactants at both the epidermal and follicular BMZs was significantly larger in the DLE group than in the BP group. On an average, ≥3 immunoreactants were seen at the epidermal and follicular BMZs in DLE, whereas ⩽2.5 immunoreactants were seen in BP. DIF may contribute to the differentiation between these 2 diseases.