Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor
Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor
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DOI：
10.1111/cei.12002
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发表时间：
2013-02-01
影响因子：
4.6
通讯作者：
Oksenhendler, E.
中科院分区：
文献类型：
--
作者：
Gouilleux-Gruart, V.;Chapel, H.;Oksenhendler, E.
常见变异性免疫缺陷疾病（CVID）的治疗是基于使用静脉内（i.v.）或皮下注射（s.c.）免疫球蛋白（IG）G. IgG剂量的个体间差异是常见的。分析了来自两个前瞻性队列的共380例接受稳定IgG替代治疗的CVID患者。效率指数定义为血清IgG谷水平减去IgG残留与IgG输注的平均每周剂量的比值。IgG的效率降低与静脉途径独立相关（P？
Treatment of common variable immunodeficiency disorders (CVID) is based on replacement therapy using intravenous (i.v.) or subcutaneous (s.c.) immunoglobulin (Ig)G. Interindividual variation of IgG dose is common. A total of 380 CVID patients on stable IgG replacement from two prospective cohorts were analysed. An efficiency index was defined as the ratio of serum IgG trough level minus IgG residual to the average weekly dose of IgG infusion. A reduced efficiency of IgG was associated independently with the i.v. route (P?