Effect of cigarette smoking on sputum smear conversion in adults with active pulmonary tuberculosis
Effect of cigarette smoking on sputum smear conversion in adults with active pulmonary tuberculosis
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DOI：
10.1016/j.rmed.2004.08.016
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发表时间：
2005-04-01
影响因子：
4.3
通讯作者：
Sharma, PN
中科院分区：
文献类型：
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作者：
Abal, AT;Jayakrishnan, B;Sharma, PN
虽然影响结核病痰涂片转换的因素已经研究得很好，吸烟的影响在很大程度上是未知的。排除那些不完整的历史或耐药菌株，339例患者的526痰阳性患者在1998年和2000年之间登记的研究。在2个月结束时，吸烟者和非吸烟者痰菌阴转的频率几乎相同{P = 0.065，OR（95%CI）0.47（0.21-1.06）}。虽然性别或年龄没有影响痰液转换方面的吸烟状况，外籍吸烟者作为一个整体表现出显着差异。（P = 0.039）。在应用逻辑回归模型时，发现具有晚期放射学异常（P < 0.038）或具有3+涂片状态（P = 0.011）的吸烟者具有较低的早期涂片转换的机会。总之，吸烟并不影响结核病痰涂片转换。然而，由于外籍吸烟者和晚期疾病吸烟者的涂片转换延迟，肺结核患者应不鼓励吸烟。(c)2004爱思唯尔有限公司保留所有权利。
Although factors influencing sputum smear conversion in tuberculosis have been studied well, the effect of smoking is largely unknown. Excluding those with incomplete history or drug resistant isolates, 339 patients out of the 526 sputum positive patients registered between 1998 and 2000 were studied. At the end of 2 months, smokers and non-smokers converted with almost the same frequency to a negative sputum status {P = 0.065, OR (95%CI) 0.47 (0.21-1.06)}. Although gender or age had no effect on sputum conversion with respect to smoking status, expatriate smokers as a whole showed a significant difference. (P = 0.039). On applying logistic regression model, smokers with far advanced radiographic abnormalities (P < 0.038) or with 3+ smear status (P = 0.011), were found to have a less chance of an early smear conversion. In conclusion smoking did not influence sputum smear conversion in tuberculosis. However, as expatriate smokers and smokers with advanced disease showed a delay in smear conversion, smoking should be discouraged in patients with pulmonary tuberculosis. (c) 2004 Elsevier Ltd. All rights reserved.