Dissociation of automatic and strategic lexical-semantics: Functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions
Dissociation of automatic and strategic lexical-semantics: Functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions
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DOI：
10.1523/jneurosci.0808-06.2006
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发表时间：
2006-06-14
影响因子：
5.3
通讯作者：
Andersen, Anders H.
中科院分区：
文献类型：
--
作者：
Gold, Brian T.;Balota, David A.;Andersen, Anders H.
行为研究已经证明了词汇-语义加工系统的三个主要组成部分：语义表征的自动激活、语义表征的策略提取和竞争对手的抑制。然而，这些组件的过程是固有的合并在明确的词汇语义决策任务通常用于功能性磁共振成像（fMRI）的研究。在这里，我们联合收割机的行为启动研究的逻辑和功能磁共振成像启动的神经生理学现象分离的神经基础的自动和策略的词汇语义过程中的一系列的三个研究。所有研究均采用单一的词汇判断任务，刺激起始时间或启动与目标之间的语言关系被操纵。研究1显示自动语义启动在左侧梭状回中（mid-FFG），策略语义启动在左侧颞中回（MTG）、双侧扣带回前部、左前下前额叶皮层（aLIPC）和后LIPC（pLIPC）五个区域。在随后的两项研究中，更详细地探讨了这些启动效应。研究2重复了中FFG的自动启动效应，并证明了该区域的自动启动优先于语义域。研究3显示了一个有助于策略语义启动效应的区域的神经分离。在aLIPC和MTG中观察到策略语义易化，而在pLIPC和前扣带回中观察到策略语义抑制。这些研究为词汇语义加工系统的三个成熟组成部分之间的神经分离提供了可重复的证据。
Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation of semantic representations, strategic retrieval of semantic representations, and inhibition of competitors. However, these component processes are inherently conflated in explicit lexical-semantic decision tasks typically used in functional magnetic resonance imaging (fMRI) research. Here, we combine the logic of behavioral priming studies and the neurophysiological phenomenon of fMRI priming to dissociate the neural bases of automatic and strategic lexical-semantic processes across a series of three studies. A single lexical decision task was used in all studies, with stimulus onset asynchrony or linguistic relationship between prime and target being manipulated. Study 1 demonstrated automatic semantic priming in the left mid-fusiform gyrus (mid-FFG) and strategic semantic priming in five regions: left middle temporal gyrus (MTG), bilateral anterior cingulate, anterior left inferior prefrontal cortex (aLIPC), and posterior LIPC (pLIPC). These priming effects were explored in more detail in two subsequent studies. Study 2 replicated the automatic priming effect in mid-FFG and demonstrated that automatic priming in this region is preferential for the semantic domain. Study 3 demonstrated a neural dissociation in regions contributing to the strategic semantic priming effect. Strategic semantic facilitation was observed in the aLIPC and MTG, whereas strategic semantic inhibition was observed in the pLIPC and anterior cingulate. These studies provide reproducible evidence for a neural dissociation between three well established components of the lexical-semantic processing system.