Psychiatric and Medical Profiles of Autistic Adults in the SPARK Cohort
Psychiatric and Medical Profiles of Autistic Adults in the SPARK Cohort
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DOI：
10.1007/s10803-020-04414-6
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发表时间：
2020-02-24
影响因子：
3.9
通讯作者：
Chung, Wendy
中科院分区：
文献类型：
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作者：
Fombonne, Eric;Snyder, LeeAnne Green;Chung, Wendy
本研究调查了参与美国SPARK研究队列的2917名自闭症成年人的照顾者报告的终生医疗和精神疾病发病率。参与者中78.4%为男性，47.3%有智力残疾，32.1%有持续性语言障碍。儿童期语言障碍（59.7%）、言语/发音问题（32.8%）、睡眠（39.4%）和进食问题（29.4%）、运动延迟（22.8%）和癫痫发作史（15.5%）是最常报告的临床特征。超过三分之二（67.2%）被诊断患有至少一种精神疾病（焦虑症：41.1%; ADHD：38.7%）。与语言流利的参与者相比，那些有语言障碍的人几乎所有精神疾病的频率都较低。女性和年龄较大与较高的医疗和精神病发病率。
This study examined lifetime medical and psychiatric morbidity reported by caregivers of 2917 autistic adults participating in the US research cohort SPARK. Participants were 78.4% male, 47.3% had intellectual disability, and 32.1% had persistent language impairments. Childhood language disorders (59.7%), speech/articulation problems (32.8%), sleep (39.4%) and eating problems (29.4%), motor delays (22.8%) and history of seizure (15.5%) were the most frequently reported clinical features. Over two thirds (67.2%) had been diagnosed with at least one psychiatric disorder (anxiety disorders: 41.1%; ADHD: 38.7%). Compared to verbally fluent participants, those with language impairments had lower frequencies of almost all psychiatric disorders. Female sex and older age were associated with higher medical and psychiatric morbidity.