Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia
Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia
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DOI：
10.1016/s0304-3959(01)00443-2
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发表时间：
2002-03-01
期刊：
影响因子：
7.4
通讯作者：
Lindblom, U
中科院分区：
文献类型：
--
作者：
Berglund, B;Harju, EL;Lindblom, U
研究人员对 20 名患有纤维肌痛综合征 (FMS) 的女性和 20 名健康年龄匹配的女性对照者进行了体感感知阈值、感知强度和感知质量的评估。所有患者和对照组都测量了随机热（Thermotest）和触觉（范弗雷丝）刺激的感知强度并描述了感知质量。感知强度通过自由数字幅度估计进行缩放，个体间可比性通过主缩放来实现。通过从列表中选择口头描述符来评估感知质量。大鱼际被用作每种测试方式的参考。所有患者都能够可靠地衡量大鱼际以及受疼痛影响的身体区域的感知强度。冷痛的感知阈值。患者的热痛、冷痛耐受性和热痛耐受性显着低于对照组。对于冷刺激和触觉刺激，患者疼痛区域的主尺度感知强度显着较高，而对于温暖/热刺激。强度明显较低。在定性知觉分析中，最引人注目和最重要的发现是所有患者的冷诱发知觉异常，大多数 30-10°C 范围内的刺激被报告为热或其他感觉异常或感觉迟钝知觉。温暖的感知品质。和触摸方面，与控件没有什么不同。在热刺激和触觉刺激的伤害感受范围中观察到另一个异常，与对照组相比，与疼痛相关的描述符明显更频繁。这表明除了较低的热痛阈值之外，还存在一般的伤害感受促进作用。冷感觉过敏冷感觉迟钝和多模式痛觉过敏的组合表明在特定整合水平上的选择性病理生理学，可能在岛皮层中。这表明超阈值感觉评估所揭示的畸变可能是 FMS 的共性。特别是，在所有患者中建立的冷感觉通道中感知质量和强度的畸变可能是附加的诊断标准。 (C) 2002 年国际疼痛研究协会。由 Elsevier Science B.V. 出版。保留所有权利。
Somatosensory perception thresholds, perceived intensity, and quality of perceptions were assessed in 20 women with fibromyalgia syndrome (FMS) and in 20 healthy age-matched female controls. All patients and controls scaled perceived intensity and described perceived quality of randomized thermal (Thermotest) and tactile (van Frey filaments) stimulation. Perceived intensity was scaled by free-number magnitude estimation and interindividual comparability was accomplished by Master Scaling. Perceived quality was assessed by choosing verbal descriptors from a list. Thenar was used as a reference for each modality tested. All patients were able to reliably scale perceived intensity at thenar, as well as in pain-affected body areas. Perception thresholds for cold pain. heat pain, cold-pain tolerance and heat-pain tolerance were significantly lower in patients than controls. For cold and tactile stimulation, the master scaled perceived intensities were significantly higher in patients' pain-affected areas, whereas for warmth/heat stimulation. the intensities were significantly lower. In the qualitative perceptual analysis the most striking and significant finding was the aberration of cold-evoked perceptions in all patients most stimuli in the range of 30-10degreesC were reported as heat or other paresthetic or dysesthetic perceptions. The perceptual quality of warmth. and of touch, did not differ from the controls. Another aberration was observed in the nociceptive range of thermal and of tactile stimulation as significantly more frequent pain-related descriptors than in controls. This indicates a general nociceptive facilitation in addition to the lower thermal pain thresholds. The combination of cold hyperesthesia cold dysesthesia, and multimodal hyperalgesia suggests a selective pathophysiology at a particular level of integration, possibly in the insular cortex, It is suggested that the aberrations revealed by the supraliminal sensory evaluation may be generic for FMS. Particularly, the aberrations established in all patients for perceived quality and intensity in the cold sensory channel may be an additional diagnostic criterion. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.