Audiovestibular Findings in a Cohort of Patients with Chiari Malformation Type I and Dizziness.
Audiovestibular Findings in a Cohort of Patients with Chiari Malformation Type I and Dizziness.
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DOI：
10.3390/jcm12082767
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发表时间：
2023-04-07
影响因子：
3.9
通讯作者：
Brewer, Carmen C.
中科院分区：
文献类型：
--
作者：
Famili, Hannah P.;Zalewski, Christopher K.;Ibrahimy, Alaaddin;Mack, Jessica;Cantor, Fredric;Heiss, John D.;Brewer, Carmen C.
关键词：
基亚里畸形I型（CM 1）是一种神经系统疾病，其中小脑扁桃体延伸超过枕骨大孔。虽然许多研究报告了CM 1患者的头晕症状，但外周血管病变的患病率在很大程度上尚不清楚。本研究的目的是全面描述一组明确提到头晕的CM 1患者的听前庭表型。评价了24例CM 1和主诉头晕/眩晕的患者。听力和听性脑干束功能基本正常。虽然前庭异常在旋转测试中最常见（33%），但功能平衡异常是最常见的发现（40%）。CM 1患者表现出异常感觉组织测试（SOT）姿势稳定性评分的固定平台条件下，和体感分析评分的可能性更大。虽然扁桃体异位程度与任何前庭/平衡结果测量之间没有显著相关性，但颈部疼痛与体感分析评分之间存在显著负相关性。躯体感觉领域的异常功能平衡是显著的，与颈部疼痛相关的评分较差。仅8%的患者存在孤立性外周前庭病变。尽管前庭病变的患病率较低，但前庭/平衡评估是必要的，以确定可能受益于转诊到专业医学学科的患者。
Chiari Malformation Type I (CM1) is a neurological condition in which the cerebellar tonsils extend past the foramen magnum. While many studies have reported dizziness symptoms in patients with CM1, the prevalence of peripheral labyrinthine lesions is largely unknown. This study aimed to comprehensively describe the audiovestibular phenotype in a cohort of patients with CM1 expressly referred for dizziness. Twenty-four patients with CM1 and a complaint of dizziness/vertigo were evaluated. Hearing and auditory brainstem tract function were essentially normal. While vestibular abnormalities were most prevalent during rotational testing (33%), abnormal functional balance was the most common finding (40%). Patients with CM1 had a greater likelihood of exhibiting an abnormal sensory organization test (SOT) postural stability score for fixed platform conditions, and for the somatosensory analysis score. While no significant associations were identified between tonsillar ectopia extent and any vestibular/balance outcome measure, a significant negative association was identified between neck pain and the somatosensory sensory analysis score. Abnormal functional balance in the somatosensory domain was remarkable, with poorer scores associated with neck pain. An isolated peripheral vestibulopathy was present in only 8% of patients. Despite the low prevalence of vestibulopathy, vestibular/balance assessment is warranted to identify patients who may benefit from referral to specialized medical disciplines.
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影响因子：
1.7
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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