Chiral Phosphapalladacycles as Efficient Catalysts for the Asymmetric Hydrophosphination of Substituted Methylidenemalonate Esters: Direct Access to Functionalized Tertiary Chiral Phosphines
Chiral Phosphapalladacycles as Efficient Catalysts for the Asymmetric Hydrophosphination of Substituted Methylidenemalonate Esters: Direct Access to Functionalized Tertiary Chiral Phosphines
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DOI：
10.1021/om201115n
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发表时间：
2012-03
期刊：
影响因子：
2.8
通讯作者：
Chang Xu;Gan Jun Hao Kennard;Felix Hennersdorf;Yongxin Li;S. Pullarkat;P. Leung
中科院分区：
文献类型：
--
作者：
Chang Xu;Gan Jun Hao Kennard;Felix Hennersdorf;Yongxin Li;S. Pullarkat;P. Leung
报道了一种手性钯环促进的取代亚甲基丙二酸酯的不对称氢化膦化反应，该反应可直接得到手性叔膦。筛选三个容易获得的C，N和C，P palladacycles作为催化剂，这种合成方案提供了深入了解催化剂设计中的关键因素，影响Pd（II）催化的不对称P-H加成反应，涉及这种活化底物的活化和立体化学。
A chiral palladacycle-promoted enantioselective asymmetric hydrophosphination of substituted methylidenemalonate esters using diphenylphosphine that provides direct access to chiral tertiary phosphines is reported. Screening of three easily accessible C,N and C,P palladacycles as catalysts for this synthetic scenario provided insights into critical factors in catalyst design that influence the activation and stereochemistry in Pd(II)-catalyzed asymmetric P–H addition reactions involving such activated substrates.