Molecular basis of contact inhibition of locomotion.
Molecular basis of contact inhibition of locomotion.
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DOI：
10.1007/s00018-015-2090-0
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Mayor R
中科院分区：
文献类型：
--
作者：
Roycroft A;Mayor R
运动的接触抑制（CIL）是一个复杂的过程，其中经历与另一个细胞碰撞的细胞停止它们向碰撞细胞的迁移。CIL已经在发育期间的许多细胞中被鉴定，包括胚胎成纤维细胞、神经嵴细胞和血细胞，并且是包括集体细胞迁移和分散的一系列现象背后的驱动力。CIL对健康组织的正常行为的丧失长期以来一直与癌细胞的侵袭有关。CIL是一个多步骤的过程，由分子机器的紧密协调驱动。在这篇综述中，我们将CIL分解成不同的步骤，并强调了驱动这一过程的每一步所涉及的关键分子机制和组件。
Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process.