Natural Human Infections With Plasmodium cynomolgi and Other Malaria Species in an Elimination Setting in Sabah, Malaysia
Natural Human Infections With Plasmodium cynomolgi and Other Malaria Species in an Elimination Setting in Sabah, Malaysia
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DOI：
10.1093/infdis/jiz397
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发表时间：
2019-12-15
影响因子：
6.4
通讯作者：
Fornace, Kimberly M.
中科院分区：
文献类型：
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作者：
Grignard, Lynn;Shah, Sonal;Fornace, Kimberly M.
为了确定疟疾感染的存在和物种组成，我们筛选了在北方沙巴，马来西亚使用高灵敏度的分子技术的横断面调查期间收集的样本的子集。结果确定了54个无症状的亚显微疟疾感染，包括一个大的恶性疟原虫集群和3个诺氏疟原虫感染。我们还确定了2个单一感染人畜共患疟疾食蟹猴疟原虫，无论是在个人报告没有历史的森林活动或接触猕猴。结果强调需要改进监测战略，以发现这些感染并确定公共卫生影响。
To determine the presence and species composition of malaria infections, we screened a subset of samples collected during a cross-sectional survey in Northern Sabah, Malaysia using highly sensitive molecular techniques. Results identified 54 asymptomatic submicroscopic malaria infections, including a large cluster of Plasmodium falciparum and 3 P. knowlesi infections. We additionally identified 2 monoinfections with the zoonotic malaria Plasmodium cynomolgi, both in individuals reporting no history of forest activities or contact with macaques. Results highlight the need for improved surveillance strategies to detect these infections and determine public health impacts.