Transmission potential of Mayaro virus in Florida Aedes aegypti and Aedes albopictus mosquitoes
Transmission potential of Mayaro virus in Florida Aedes aegypti and Aedes albopictus mosquitoes
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DOI：
10.1111/mve.12322
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发表时间：
2018-12-01
影响因子：
1.9
通讯作者：
Alto, B. W.
中科院分区：
文献类型：
--
作者：
Wiggins, K.;Eastmond, B.;Alto, B. W.
马亚罗病毒（MAYV）是一种新出现的蚊媒虫媒病毒，存在于中美洲和南美洲，引起关节痛和发热性疾病。埃及伊蚊（双翅目：蚊科）和白纹伊蚊是MAYV的潜在传播媒介，可能会在城市环境中传播给人类。本文评估了佛罗里达Ae.埃及伊蚊和埃及伊蚊。白纹伊蚊为MAYV。口腔感染明显高于Ae。白纹伊蚊（85-100%）比Ae.埃及人（67-82%）。病毒传播到血腔在Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊传播迅速，并与唾液腺感染同时发生。播散性感染率普遍较高的Ae。aegypti（45-85%）比Ae.白纹伊蚊（38-76%），尽管差异仅在喂食MAYV感染的血液后9天才显着。两种蚊子的唾液痰中MAYV感染率较低。蚊子体内的病毒滴度随着吸血后天数的增加而增加，并且在Ae中更高。比在Ae.白纹伊蚊虽然佛罗里达蚊媒有可能传播MAYV，从而在吸食较高滴度的MAYV感染血液后启动城市循环，但感染人群中较低的病毒血症可能限制传播潜力。
Mayaro virus (MAYV) is an emerging mosquito-borne arbovirus present in Central and South America that causes arthralgia and febrile illness. Domestic mosquitoes Aedes aegypti (Diptera: Culicidae) and Aedes albopictus are potential vectors of MAYV that may allow for transmission to humans in urban settings. The present paper assesses susceptibility to infection, disseminated infection and transmission potential in Florida Ae. aegypti and Ae. albopictus for MAYV. Oral infection was significantly higher in Ae. albopictus (85-100%) than in Ae. aegypti (67-82%). Viral dissemination to the haemocoel in Ae. aegypti and Ae. albopictus mosquitoes was rapid and co-occurred with infection of the salivary glands. Rates of disseminated infection were generally higher in Ae. aegypti (45-85%) than in Ae. albopictus (38-76%), although the difference was significant only at 9 days after feeding on MAYV-infected blood. Both mosquito species exhibited low rates of MAYV infection in saliva expectorates. Viral titres in the bodies of mosquitoes increased in line with the number of days post-blood feeding and were higher in Ae. aegypti than in Ae. albopictus. Although Florida mosquito vectors have the potential to transmit MAYV and thus to initiate an urban cycle after having fed on higher titres of MAYV-infected blood, lower viraemia in infected humans is likely to limit transmission potential.