Accuracy and reproducibility of manual and semiautomated quantification of MS lesions by MRI
Accuracy and reproducibility of manual and semiautomated quantification of MS lesions by MRI
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DOI：
10.1002/jmri.10258
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发表时间：
2003-03-01
影响因子：
4.4
通讯作者：
Ekholm, S
中科院分区：
文献类型：
--
作者：
Ashton, EA;Takahashi, C;Ekholm, S
目的：评估两种半局部方法的准确性，可重复性和速度，以量化多发性硬化症患者中的全白质病变负担（MS）患者的手动跟踪以及最近文献中提出的其他方法。检查了MRI对MS患者的半小量定量化总病变负担的定量。第一种方法是几何约束区域生长（GEORG），需要用户对病变位置的规范。第二种技术，定向多光谱分段（DMS），仅需要单个示例性病变的位置。测试数据集包括临床MS数据和MS Brain Phantom。回报：手动跟踪的平均处理时间为60分钟，区域增长10分钟，定向分段为3分钟。手动跟踪的变异和互操作系数为5.1％和16.5％，区域增长率为1.4％和2.3％，有针对性分段为1.5％和5.2％。区域增长的平均偏差为9％，定向分段的平均偏差为5.7％。结论：在速度和精确方面，这两种半小动物的方法都比手动跟踪具有显着优势。考虑到手动结果的较高可变性，两种方法的准确性都是可以接受的。
Purpose: To evaluate the accuracy, reproducibility, and speed of two semiautomated methods for quantifying total white matter lesion burden in multiple sclerosis (MS) patients with respect to manual tracing and to other methods presented in recent literature.Materials and Methods: Two methods involving the use of MRI for semiautomated quantification of total lesion burden in MS patients were examined. The first method, geometrically constrained region growth (GEORG), requires user specification of lesion location. The second technique, directed multispectral segmentation (DMSS), requires only the location of a single exemplar lesion. Test data sets included both clinical MS data and MS brain phantoms.Results: The mean processing times were 60 minutes for manual tracing, 10 minutes for region growth, and 3 minutes for directed segmentation. Intra- and interoperator coefficients of variation (CVs) were 5.1% and 16.5% for manual tracing, 1.4% and 2.3% for region growth, and 1.5% and 5.2% for directed segmentation. The average deviations from manual tracing were 9% for region growth and 5.7% for directed segmentation.Conclusion: Both semiautomated methods were shown to have a significant advantage over manual tracing in terms of speed and precision. The accuracy of both methods was acceptable, given the high variability of the manual results.