A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates
A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates
复制标题
DOI：
10.4269/ajtmh.2001.65.177
复制
发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Kemp, DJ
中科院分区：
文献类型：
--
作者：
Currie, BJ;Mayo, M;Kemp, DJ
在28个月的时间里，澳大利亚北领地顶端一个偏远的小土著社区的成员发生了9例类鼻疽病，其中4例死亡。脉冲场凝胶电泳分型结果显示，从6例病例中分离出的假马勒伯克氏菌为克隆株，且与从社区供水中分离出的伯克氏菌相同，但与土壤分离株不同。在该群中发现的分离株的克隆性与在该地区发现的假芽孢杆菌高地方性的人类和环境分离株的显著遗传多样性形成对比。该克隆菌可能在供水系统的生物膜中持续存在并繁殖。虽然传播给人类的确切方式和疫情停止的原因仍不确定，但未氯化的社区供水受到污染可能是一个解释。
Nine cases of melioidosis with four deaths occurred over a 28-month period in members of a small remote Aboriginal community in the top end of the Northern Territory of Australia. Typing by pulsed-field gel electrophoresis showed isolates of Burkholderia pseudomallei from six of the cases to be clonal and also identical to an isolate from the community water supply, but not to soil isolates. The clonality of the isolates found in this cluster contrasts with the marked genetic diversity of human and environmental isolates found in this region which is hyperendemic for B. pseudomallei. It is possible that the clonal bacteria persisted and were propagated in biofilm in the water supply system. While the exact mode of transmission to humans and the reasons for cessation of the outbreak remain uncertain, contamination of the unchlorinated community water supply is a likely explanation.