AZICEMICIN-A AND AZICEMICIN-B, NEW ANTIMICROBIAL AGENTS PRODUCED BY AMYCOLATOPSIS .2. STRUCTURE DETERMINATION
AZICEMICIN-A AND AZICEMICIN-B, NEW ANTIMICROBIAL AGENTS PRODUCED BY AMYCOLATOPSIS .2. STRUCTURE DETERMINATION
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DOI：
10.7164/antibiotics.48.1148
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发表时间：
1995-10-01
影响因子：
3.3
通讯作者：
TAKEUCHI, T
中科院分区：
文献类型：
--
作者：
TSUCHIDA, T;SAWA, R;TAKEUCHI, T
从无枝霉发酵液中分离得到一个新的结构类抗生素--阿奇霉素A(1)和B(2)。MJ126-NF4。其结构经理化性质、核磁共振实验和化学转化确定为3-(1-甲基-2-氮杂环丁基)-和3-(2-氮杂环丁基)-3，4-二氢-3，7，8，10，12b-五羟基-9，12-二甲氧基苯并[a]菲-1，6(2H，SH)-二酮。
A new structural class of antibiotics, azicemicins A (1) and B (2) were isolated from the culture broth of Amycolatopsis sp. MJ126-NF4. Their structures were elucidated from their physico-chemical properties, various NMR experiments and chemical transformations and were shown to be 3-(1-methyl-2-aziridinyl)- and 3-(2-aziridinyl)-3,4-dihydro-3,7,8,10, 12b-pentahydroxy-9, 12-dimethoxybenz[a]anthracene-1,6(2H,SH)-dione, respectively.