GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus
GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus
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DOI：
10.1515/revneuro-2018-0014
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发表时间：
2019-04-01
影响因子：
4.1
通讯作者：
Hernandez-Lopez, Salvador
中科院分区：
文献类型：
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作者：
Hernandez-Vazquez, Fabiola;Garduno, Julieta;Hernandez-Lopez, Salvador
中缝背核（DRN）位于脑干，参与睡眠、温度调节、应激反应和焦虑行为等多种功能。这个核包含了大脑中最多的血清素表达神经元。5 -羟色胺能DRN神经元接受来自多个脑区以及同一核内的中间神经元的强直性氨基丁酸（GABA）抑制输入。DRN中的5 -羟色胺能神经元和gaba能神经元可以通过它们的大小、位置、药理反应和电生理特性来区分。gaba能神经元调节DRN - 5 -羟色胺能神经元的兴奋性和不同脑区血清素的释放。此外，gaba能神经元可以同步5 -羟色胺能神经元在睡眠或警觉等功能上的活动。此外，DRN中GABA信号的失调与精神疾病如焦虑和抑郁有关。本文就gaba能在DRN中的传递进行综述。gaba能和5 -羟色胺能神经元之间的相互作用进行了讨论，并考虑了一些生理意义。此外，还描述了5 -羟色胺能神经元和gaba能神经元的主要电生理和形态学特征。
The dorsal raphe nucleus (DRN), located in the brainstem, is involved in several functions such as sleep, temperature regulation, stress responses, and anxiety behaviors. This nucleus contains the largest population of serotonin expressing neurons in the brain. Serotonergic DRN neurons receive tonic y-aminobutyric acid (GABA) inhibitory inputs from several brain areas, as well as from interneurons within the same nucleus. Serotonergic and GABAergic neurons in the DRN can be distinguished by their size, location, pharmacological responses, and electrophysiological properties. GABAergic neurons regulate the excitability of DRN serotonergic neurons and the serotonin release in different brain areas. Also, it has been shown that GABAergic neurons can synchronize the activity of serotonergic neurons across functions such as sleep or alertness. Moreover, dysregulation of GABA signaling in the DRN has been linked to psychiatric disorders such as anxiety and depression. This review focuses on GABAergic transmission in the DRN. The interaction between GABAergic and serotonergic neurons is discussed considering some physiological implications. Also, the main electrophysiological and morphological characteristics of serotonergic and GABAergic neurons are described.