Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa, 2009-2011.
Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa, 2009-2011.
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DOI：
10.3201/eid1911.130546
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发表时间：
2013-11
影响因子：
11.8
通讯作者：
Madhi SA
中科院分区：
文献类型：
--
作者：
Cohen C;Moyes J;Tempia S;Groom M;Walaza S;Pretorius M;Dawood H;Chhagan M;Haffejee S;Variava E;Kahn K;Tshangela A;von Gottberg A;Wolter N;Cohen AL;Kgokong B;Venter M;Madhi SA
艾滋病毒感染者的流感流行病学数据有限，特别是在艾滋病毒感染广泛的撒哈拉以南非洲。我们检测了2009-2011年期间在南非住院的急性下呼吸道感染患者的呼吸道和血液样本，以检测病毒和肺炎球菌感染。在9%（1，056/11，925）的入组患者中确定了流感;在流感病例患者中，819名接受检测的患者中有358名（44%）感染了艾滋病毒。艾滋病毒感染者（186-228/100，000）的流感相关急性下呼吸道感染发病率是未感染艾滋病毒者（26-54/100，000）的4-8倍。此外，多变量分析显示，HIV感染者更可能合并肺炎球菌感染;与A型相比，感染B型流感;住院2-7天或>7天;以及死于疾病。这些发现表明，艾滋病毒感染者患流感相关严重疾病的风险更大，因此应优先接种流感疫苗。
Data on influenza epidemiology in HIV-infected persons are limited, particularly for sub-Saharan Africa, where HIV infection is widespread. We tested respiratory and blood samples from patients with acute lower respiratory tract infections hospitalized in South Africa during 2009–2011 for viral and pneumococcal infections. Influenza was identified in 9% (1,056/11,925) of patients enrolled; among influenza case-patients, 358 (44%) of the 819 who were tested were infected with HIV. Influenza-associated acute lower respiratory tract infection incidence was 4–8 times greater for HIV-infected (186–228/100,000) than for HIV-uninfected persons (26–54/100,000). Furthermore, multivariable analysis showed HIV-infected patients were more likely to have pneumococcal co-infection; to be infected with influenza type B compared with type A; to be hospitalized for 2–7 days or >7 days; and to die from their illness. These findings indicate that HIV-infected persons are at greater risk for severe illnesses related to influenza and thus should be prioritized for influenza vaccination.
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DOI：
10.1016/s1473-3099(06)70466-2
发表时间：
2006-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Brundage JF
通讯作者：
Brundage JF
DOI：
10.1097/00126334-200311010-00008
发表时间：
2003-11-01
影响因子：
3.6
作者：
Neuzil, KM;Coffey, CS;Griffin, MR
通讯作者：
Griffin, MR
影响因子：
5.5
作者：
Noymer, Andrew
通讯作者：
Noymer, Andrew
影响因子：
168.9
作者：
Jamieson, Denise J.;Honein, Margaret A.;Olsen, Sonja J.
通讯作者：
Olsen, Sonja J.
影响因子：
3.7
作者：
Feikin DR;Njenga MK;Bigogo G;Aura B;Aol G;Audi A;Jagero G;Muluare PO;Gikunju S;Nderitu L;Balish A;Winchell J;Schneider E;Erdman D;Oberste MS;Katz MA;Breiman RF
通讯作者：
Breiman RF