RED FLUORESCENCE OF EXPERIMENTALLY INDUCED AND HUMAN TUMOURS
RED FLUORESCENCE OF EXPERIMENTALLY INDUCED AND HUMAN TUMOURS
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DOI：
10.1002/path.1700800218
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发表时间：
1960-01-01
期刊：
影响因子：
--
通讯作者：
GHADIALLY, FN
中科院分区：
文献类型：
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作者：
GHADIALLY, FN
致癌物诱发的兔子、小鼠、仓鼠和刺猬的鳞状细胞癌在溃疡时，在紫外线下显示红色荧光，就像它们在人身上所做的那样。大鼠的皮肤纤维肉瘤在溃疡表面也显示红色荧光。实验动物皮肤的一些良性上皮肿瘤显示红色荧光;这尤其见于皮肤其他部位携带荧光癌的动物。创伤性溃疡通常不会显示红色荧光，但一只患有鳞状细胞癌的兔子的一处溃疡呈阳性。将红色荧光坏死物质从癌转移到正常兔的创伤性溃疡中，在这些溃疡中没有建立红色荧光。结果不支持红色荧光是由于肿瘤溃疡表面微生物活性产生的卟啉的想法。
Carcinogen-induced squamous cell carcinomas in the rabbit, mouse, hamster and hedgehog, when ulcerated, show a red fluorescence with UV light, just as they do in man. Dermato-fibrosarcomas in the rat also showed red fluorescence on their ulcerated surfaces. Some benign epithelial tumors of the skin of experimental animals show red fluorescence; this was seen especially in animals bearing a fluorescent carcinoma elsewhere on the skin. Traumatic ulcers do not generally show red fluorescence, but one ulcer in a rabbit bearing a squamous cancer became positive. Transfer of red fluorescent necrotic material from carcinomas to traumatic ulcers in normal rabbits did not establish red fluorescence in these ulcers. The results do not support the idea that the red fluorescence is due to porphyrins produced by microbial activity on the ulcerated surface of tumors.