Cerebellar neuronal activity expresses the complex topography of conditioned eyeblink responses
Cerebellar neuronal activity expresses the complex topography of conditioned eyeblink responses
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DOI：
10.1037/0735-7044.117.6.1211
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Moore, JW
中科院分区：
文献类型：
--
作者：
Choi, JS;Moore, JW
巴甫洛夫眨眼条件反射是研究条件刺激和非条件刺激之间的时间关系在大脑中如何表现的一个有用的模型系统。作为一个例子，在复杂的条件反射模式下形成的反应形貌，涉及2个随机交替的刺激间间隔（ISI），表现出条件反射（CR），具有2个独特的峰，对应于2个ISI。作者提出了第一个完整的报告，在小脑间位核的神经元活动的兔子进行双峰反应。所有CR相关的活动表现出的放电模式，高度相关，并在眨眼反应。双峰CRs和神经元反应的时间过程之间的惊人的相似性表明，小脑中的神经元活动与行为CRs的产生有因果关系。
Pavlovian eyeblink conditioning is a useful model system for studying how the temporal relationship between a conditioned stimulus and an unconditioned stimulus is represented in the brain. As an example, the response topography formed under a complex conditioning paradigm, involving 2 randomly alternating interstimulus intervals (ISIs), manifests a conditioned response (CR) with 2 distinctive peaks that correspond to the 2 ISIs. The authors present the first full report of neuronal activities in the cerebellar interpositus nucleus of rabbits performing bimodal responses. All CR-related activities exhibited firing patterns that highly correlated with and preceded eyeblink responses. The striking similarity between the time course of bimodal CRs and neuronal responses indicates that neuronal activities in the cerebellum are causally related to the production of behavioral CRs.