Thyroid secretion in the unanesthetized, stress-free rat and its suppression by pentobarbital.
Thyroid secretion in the unanesthetized, stress-free rat and its suppression by pentobarbital.
复制标题
未麻醉、无应激大鼠的甲状腺分泌及其戊巴比妥的抑制。
DOI：
10.1159/000122047
复制
发表时间：
1972
影响因子：
4.1
通讯作者：
G. Hedge
中科院分区：
文献类型：
--
作者：
M. Brown;G. Hedge
甲状腺功能进行了研究，在未麻醉的雌性大鼠，通过测定125碘水平，通过慢性颈静脉导管获得的连续血液样本。根据血浆皮质酮测定结果，与采样程序无关的任何因素均不会对动物造成压力。合成TRF和TSH注射导致血液中125 I水平的快速增加。暴露于寒冷（无论是连续或短暂）引起了类似的，但有点延迟的反应。甲状腺素预处理可消除对冷的反应。戊巴比妥麻醉时，维持每小时注射，也取消了冷反应。这至少部分是由于甲状腺对TSH的反应性降低。
Thyroid function was studied in unanesthetized female rats by determining 125I levels in sequential blood samples obtained via chronic jugular catheters. On the basis of plasma corticosterone determinations, nothing associated with the sampling procedure was stressful for the animals. Synthetic TRF and TSH injections resulted in rather rapid increases in blood 125I levels. Exposure to cold (either continuous or transient) caused a similar but somewhat delayed response. The response to cold was abolished by thyroxine pretreatment. Pentobarbital anesthesia, when maintained by hourly injections, also abolished the cold response. This was, at least in part, due to decreased responsiveness of the thyroid to TSH.