Role for netrin-1 in sensory axonal guidance in higher vertebrates.
Role for netrin-1 in sensory axonal guidance in higher vertebrates.
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DOI：
10.5387/fms.55.1
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发表时间：
2009-06
影响因子：
0.8
通讯作者：
T. Masuda;C. Sakuma;H. Yaginuma
中科院分区：
文献类型：
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作者：
T. Masuda;C. Sakuma;H. Yaginuma
在发育过程中，高等脊椎动物的背根神经节（DRG）神经元通过背根进入区（DREZ）将其轴突向脊髓中心延伸，并向肌肉和皮肤靶点延伸。进入脊髓后，DRG轴突投射到背侧套层。在这篇综述中，我们专注于证据显示netrin-1在形成感觉轴突轨迹的作用。Netrin-1是一种可扩散的轴突导向分子，其化学排斥发育中的DRG轴突。当DRG轴突向DREZ投射时，腹侧脊髓来源的netrin-1阻止DRG轴突向腹侧脊髓异常投射。在后期阶段，脊髓背侧细胞瞬时表达netrin-1。这种脊髓背侧来源的netrin-1防止DRG轴突在等待期间侵入脊髓背侧。总之，所回顾的数据提供了有力的证据，证明netrin-1在发育过程中的感觉轴突投射中起着至关重要的作用。
During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG axons project into the dorsal mantle layer. In this review, we focus on evidence showing the role for netrin-1 in forming sensory axonal trajectories. Netrin-1 is a diffusible axonal guidance molecule that chemorepels developing DRG axons. When DRG axons project toward the DREZ, ventral spinal cord-derived netrin-1 prevents DRG axons from projecting aberrantly toward the ventral spinal cord. At later stages, the dorsal spinal cord cells transiently express netrin-1. This dorsal spinal cord-derived netrin-1 prevents DRG axons from invading the dorsal spinal cord during the waiting period. Together, the data reviewed provide strong evidence that netrin-1 plays a crucial role in sensory axon projection during development.