Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing
Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing
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DOI：
10.1016/j.jff.2022.105307
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发表时间：
2022-10-29
影响因子：
5.6
通讯作者：
Shibata, Shigenobu
中科院分区：
文献类型：
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作者：
Haraguchi, Atsushi;Yamazaki, Tomohiro;Shibata, Shigenobu
尽管咖啡因对生理功能的各种影响已被证明，但咖啡因摄入对生理功能的时间依赖性影响仍有待研究。因此，本研究探讨了咖啡因摄入的最佳时间，以产生有效的减肥效果。我们准备了高脂饮食（HFD）或HFD补充0.03%咖啡因（HFD-caf）和规定的每日两次8小时限时喂养。癌症研究所雄性小鼠被分为三组：单独喂食HFD的组（对照组）、在活动期开始时喂食HFD-caf的组（BF-caf）和在活动期结束时喂食HFD-caf的组（DN-caf）。BF-caf组（42.8 +/- 1.5 g）显示出比其他组（对照组，49.7 +/- 2.1 g; DN-caf，47.1 +/- 1.3 g）更低的体重，尽管三组显示出相似的HFD摄入水平。因此，在活动期开始时摄入咖啡因可抑制HFD诱导的体重增加。
The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study inves-tigated the optimal timing of caffeine intake to produce an efficient anti-obesity effect. We prepared a high-fat diet (HFD) or HFD supplemented with 0.03% caffeine (HFD-caf) and regulated twice-daily 8-hour time-restricted feeding. Male Institute of Cancer Research mice were divided into three groups: group fed HFD alone (control), group fed HFD-caf at the beginning of the active period (BF-caf), and group fed HFD-caf at the end of the active period (DN-caf). The BF-caf group (42.8 +/- 1.5 g) showed lower body weight than the other groups (control, 49.7 +/- 2.1 g; DN-caf, 47.1 +/- 1.3 g), although the three groups showed similar HFD intake levels. Therefore, caffeine intake at the beginning of the active period suppressed HFD-induced body weight gain.