Effects of Combined Peripheral Nerve Stimulation and Brain Polarization on Performance of a Motor Sequence Task After Chronic Stroke
Effects of Combined Peripheral Nerve Stimulation and Brain Polarization on Performance of a Motor Sequence Task After Chronic Stroke
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DOI：
10.1161/strokeaha.108.540500
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发表时间：
2009-05-01
期刊：
影响因子：
8.3
通讯作者：
Cohen, Leonardo G.
中科院分区：
文献类型：
--
作者：
Celnik, Pablo;Paik, Nam-Jong;Cohen, Leonardo G.
背景和目的：最近的研究表明，单独应用外周神经和皮层刺激可以适度改善中风患者的运动表现。本研究的目的是测试的假设相结合的周围神经刺激（PNS）麻痹的手与阳极直流电刺激（tDCS）的同侧初级运动皮层（M1）将促进运动训练的有益效果比每一个单独的干预或假（tDCS（假）和PNS（假））。在单独的会话中，我们研究了在运动训练前单独应用PNS+tDCS、PNS+tDCS（Sham）、tDCS+PNS（Sham）和PNS（Sham）+tDCS（Sham）对麻痹手执行手指运动序列的能力的影响。结果-PNS +tDCS导致相对于PNS（Sham）+tDCS（Sham）的正确按键次数提高41.3%，相对于PNS+tDCS（Sham）的15.4%，和22.7%相对于tDCS+PNS（Sham）。这些性能差异保持1和6天后结束的training. Conclusions，这些结果表明，结合三七总皂苷与tDCS可以促进运动性能的训练的有益影响超出了每个干预单独达到的水平，发现中风后运动障碍的神经康复的相关性。（中风。2009; 40：1764-1771）。
Background and Purpose-Recent work demonstrated that application of peripheral nerve and cortical stimulation independently can induce modest improvements in motor performance in patients with stroke. The purpose of this study was to test the hypothesis that combining peripheral nerve stimulation (PNS) to the paretic hand with anodal direct current stimulation (tDCS) to the ipsilesional primary motor cortex (M1) would facilitate beneficial effects of motor training more than each intervention alone or sham (tDCS(Sham) and PNS(Sham)).Methods-Nine chronic stroke patients completed a blinded crossover designed study. In separate sessions, we investigated the effects of single applications of PNS+tDCS, PNS+tDCS(Sham), tDCS+PNS(Sham), and PNS(Sham)+tDCS(Sham) before motor training on the ability to perform finger motor sequences with the paretic hand.Results-PNS+tDCS resulted in a 41.3% improvement in the number of correct key presses relative to PNS(Sham)+tDCS(Sham), 15.4% relative to PNS+tDCS(Sham), and 22.7% relative to tDCS+PNS(Sham). These performance differences were maintained 1 and 6 days after the end of the training.Conclusions-These results indicate that combining PNS with tDCS can facilitate the beneficial effects of training on motor performance beyond levels reached with each intervention alone, a finding of relevance for the neurorehabilitation of motor impairments after stroke. (Stroke. 2009; 40: 1764-1771.)